Browsing by Autor "Mabel Guerra Giraldez"

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    Human Antibody Response to Aedes aegypti Saliva in an Urban Population in Bolivia: A New Biomarker of Exposure to Dengue Vector Bites
    (American Society of Tropical Medicine and Hygiene, 2012) Souleymane Doucouré; François Mouchet; Amandine Cournil; Gilbert Le Goff; Sylvie Cornélie; Yelin Roca; Mabel Guerra Giraldez; Z. Barja Simon; Roxana Loayza; Dorothée Missé
    Aedes mosquitoes are important vectors of re-emerging diseases in developing countries, and increasing exposure to Aedes in the developed world is currently a source of concern. Given the limitations of current entomologic methods, there is a need for a new effective way for evaluating Aedes exposure. Our objective was to evaluate specific antibody responses to Aedes aegypti saliva as a biomarker for vector exposure in a dengue-endemic urban area. IgG responses to saliva were strong in young children and steadily waned with age. Specific IgG levels were significantly higher in persons living in sites with higher Ae. aegypti density, as measured by using entomologic parameters. Logistic regression showed a significant correlation between IgG to saliva and exposure level, independently of either age or sex. These results suggest that antibody responses to saliva could be used to monitor human exposure to Aedes bites.