Browsing by Autor "Mahabir P. Gupta"

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    Chemical composition of essential oils of Piper jacquemontianum and Piper variabile from Guatemala and bioactivity of the dichloromethane and methanol extracts
    (Springer Science+Business Media, 2011) Sully M. Cruz; Armando Cáceres; Luis E. Álvarez; Jorge Alexander Diaz Morales; Miriam Anders Apel; Amélia Teresinha Henriques; Efraín Salamanca; Alberto Giménez; Yelkaira Vásquez; Mahabir P. Gupta
    The essential oils from two native species from Guatemala were studied for their chemical composition and the dichloromethane and methanol extracts for their biological activity. A GC-MS analysis of the essential oil from Piper jacquemontianum Kunth, Piperaceae, showed 34 constituents, consisting mainly of linalool (69.4%), while Piper variabile C. DC. essential oil had 36 constituents, camphor (28.4%), camphene (16.6%) and limonene (13.9%) being the major components. Dichloromethane extracts of both species were cytotoxic against MCF-7, H-460 and SF-268 cell lines (<7 µg/mL). Dichloromethane extract of P. jacquemontianum was slightly active against bacteria (0.5 mg/mL), was active against promastigotes of Leishmania (20.4-61.0 µg/mL), and epimastigotes of Trypanosoma cruzi (51.9 µg/mL). The methanol extract of P. variabile showed antimalarial activity against Plasmodium falciparum F32 (4.5 µg/mL), and the dichloromethane extract against Leishmania (55.8-76.3 µg/mL) and T. cruzi (45.8 µg/mL). None of the extracts from the two species was active against Aedes aegypti larvae and Artemia salina nauplii.
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    Subcutaneous antifungal screening of Latin American plant extracts against<i>Sporothrix schenckii</i>and<i>Fonsecaea pedrosoi</i>
    (Taylor & Francis, 2011) Isabel Gaitán; Ana Margarita Paz; Susana Zacchino; Giselle Tamayo‐Castillo; Alberto Giménez; Roberto Pinzón; Armando Cáceres; Mahabir P. Gupta
    S. schenkii and F. pedrosoi were inhibited by B. huanita (MIC: 12.5 and 25 µg/mL), G. gaudichaudianum (MIC: 50 and 12.5 µg/mL) and T. triflora (MIC: 25 µg/mL).
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    Treinta años de viena y diez de budapest: Donde estamos en américa latina?
    (Associação Interciencia, 2009) Carlos Aguirre Bastos; Mahabir P. Gupta
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    Unusual composition of the essential oils from the leaves of <i>Piper aduncum</i>
    (Wiley, 2004) Roser Vila; Félix Tomi; Marisa Mundina; Ana I. Santana; Pablo N. Solís; José B. López Arce; José L. Balderrama Iclina; José Iglesias; Mahabir P. Gupta; Joseph Casanova
    Abstract The chemical compositions of the essential oils from the leaves of Piper aduncum from Panama and Bolivia were investigated by GC‐FID, GC‐MS and 13 C‐NMR. In total, 55 components were identified representing 99.3 and 80.3% of each sample, respectively. The oil from Panama was characterized by a high percentage of sesquiterpene hydrocarbons (38.9%), the main ones being β ‐caryophyllene (17.4%) and aromadendrene (13.4%). In contrast, the oil from Bolivia showed a high content of monoterpenes (76%), the major constituent being 1,8‐cineole (40.5%). Phenylpropanoids, mainly sarisan (1‐allyl‐2‐methoxy‐4,5‐methylenedioxybenzene; 12.9%), were only detected in the latter. Copyright © 2004 John Wiley &amp; Sons, Ltd.