Browsing by Autor "Mariana Batista Pereira"

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Acute kidney disease in patients with COVID-19. A prospective, multicenter, multinational study in Latin America
(Sociedade Brasileira de Nefrologia, 2025) Raúl Lombardi; Alejandro Ferreiro; Joanna Yanissa Venegas Justiniano; Mariana Batista Pereira; Cristina Carlino; Rolando Claure‐Del Granado; Daniela Ponce; Daniel Molina Comboni; Agustina Zinoveev
Our data endorse a comprehensive approach based on the concept of AKD. This integrative approach, encompassing the structural and functional continuum of AKI, AKD, and CKD, enables timely interventions and the implementation of preventive and therapeutic strategies.
Doença renal aguda em pacientes com COVID-19: um estudo prospectivo, multicêntrico e multinacional na América Latina
(Sociedade Brasileira de Nefrologia, 2025) Raúl Lombardi; Alejandro Ferreiro; Joanna Yanissa Venegas Justiniano; Mariana Batista Pereira; Cristina Carlino; Rolando Claure‐Del Granado; Daniela Ponce; Daniel Molina Comboni; Agustina Zinoveev
Resumo Introdução: A doença renal aguda (DRA) é definida como anormalidades renais funcionais e/ou estruturais, com implicações para saúde e duração ≤90 dias. O objetivo foi avaliar a DRA como uma abordagem mais apropriada para essas condições, utilizando uma coorte com COVID-19, onde o comprometimento renal é expresso por proteinúria e/ou perda de função. Métodos: Estudo de coorte observacional, prospectivo, longitudinal, multinacional realizado em cinco países latino-americanos. Foram incluídos pacientes adultos com diagnóstico de COVID-19. Na internação, realizou-se urinálise ou teste de urina com tira reagente. Caso a proteína não fosse detectada, uma investigação de acompanhamento era feita cinco dias depois. Os pacientes foram classificados em quatro categorias de DRA: doença não renal, somente proteinúria, somente injúria renal aguda (IRA), proteinúria e IRA. Resultados: Foram incluídos 360 pacientes. A DRA esteve presente em 273 (75,8%), dos quais 142 (52,0%) apresentaram somente proteinúria, 11 (4,1%) IRA sem proteinúria e 120 (43,9%) apresentaram proteinúria e IRA. No geral, a proteinúria, com ou sem IRA, foi observada em 262 pacientes (72,8%). A IRA, com ou sem proteinúria, ocorreu em 131 pacientes (36,4%). A IRA foi predominantemente grave, não oligúrica e adquirida no hospital. A mortalidade hospitalar aumentou com a gravidade da DRA: doença não renal 9,5%, somente proteinúria 22,8%, somente IRA 56,7%, proteinúria mais IRA 53,0% (p = 0,001). Conclusões: Nossos dados endossam uma abordagem abrangente baseada no conceito de DRA. Essa abordagem integrativa, englobando o continuum estrutural e funcional de IRA, DRA e DRC, permite intervenções oportunas e a implementação de estratégias preventivas e terapêuticas.
EPILAT-IRA Study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America
(Public Library of Science, 2019) Raúl Lombardi; Alejandro Ferreiro; Rolando Claure‐Del Granado; Emmanuel A. Burdmann; Guillermo Rosa-Díez; Luís Yu; Maurício Younes-Ibrahim; Cristina Carlino; Jonathan S. Chávez-Íñiguez; Mariana Batista Pereira
AKI was mainly community-acquired, in patients with comorbidities and linked to fluid loss and nephrotoxic drugs. Mortality was high and long-term follow up poor. Notwithstanding, the study shows partially the situation in the participant countries rather than the actual epidemiology of AKI in Latin America and Caribbean, a pending and needed task.
Latin American Registry of renal involvement in COVID-19 disease. The relevance of assessing proteinuria throughout the clinical course
(2021) Raúl Lombardi; Alejandro Ferreiro; Daniela Ponce; Rolando Claure‐Del Granado; Gustavo Aroca; Yanissa Venegas; Mariana Batista Pereira; Jonathan S. Chávez-Íñiguez; Nelson Rojas; Ana Villa
Abstract The Latin American Society of Nephrology and Hypertension carried out a cohort prospective, multinational registry of patients with kidney impairment associated to COVID-19 in Latin America through open invitation in order to describe the characteristics of the disease in the region. A population of 870 patients from 12 countries were included. Median age was 63 years (54-74), most of patients were male (68.4%) and had comorbidities (87.2%). Acute kidney injury (AKI) was hospital-acquired in 64.7% and non-oliguric in 59.9%. Multiorgan dysfunction syndrome (MODS) due to COVID-19 and volume depletion were the main causes of AKI (59.2% and 35.7% respectively). Kidney replacement therapy was started in 46.2%. Non-recovery of renal function was observed in 65.3%. 71.5% of patients were admitted to ICU and 72.2% underwent mechanical ventilation. Proteinuria at admission was present in 62.4% of patients and proteinuria during hospital-stay occurred in 37.5%. Those patients with proteinuria at admission had higher burden of comorbidities, higher baseline sCr, higher mortality and MODS was severe. On the other hand, patients with de novo proteinuria had lower burden of comorbidities and near normal sCr at admission, but showed adverse course of disease and higher in-mortality. COVID-19 MODS was the main cause of AKI in both groups. All-cause mortality was 57.4%, and it was associated to age, chronic cardiac disease, fluid depletion, COVID-19 MODS, non-recovery of renal function, ICU admission, vasopressors, in-hospital complications and hospital stay. In conclusion, our study contributes to a better knowledge of this condition and highlights the relevance of the detection of proteinuria throughout the clinical course.
Latin American registry of renal involvement in COVID-19 disease. The relevance of assessing proteinuria throughout the clinical course
(Public Library of Science, 2022) Raúl Lombardi; Alejandro Ferreiro; Daniela Ponce; Rolando Claure‐Del Granado; Gustavo Aroca; Yanissa Venegas; Mariana Batista Pereira; Jonathan S. Chávez-Íñiguez; Nelson Rojas; Ana Villa
The Latin American Society of Nephrology and Hypertension conducted a prospective cohort, multinational registry of Latin American patients with kidney impairment associated to COVID-19 infection with the objective to describe the characteristics of acute kidney disease under these circumstances. The study was carried out through open invitation in order to describe the characteristics of the disease in the region. Eight-hundred and seventy patients from 12 countries were included. Median age was 63 years (54-74), most of patients were male (68.4%) and with diverse comorbidities (87.2%). Acute kidney injury (AKI) was hospital-acquired in 64.7% and non-oliguric in 59.9%. Multiorgan dysfunction syndrome (MODS) due to COVID-19 and volume depletion were the main factors contributing to AKI (59.2% and 35.7% respectively). Kidney replacement therapy was started in 46.2%. Non-recovery of renal function was observed in 65.3%. 71.5% of patients were admitted to ICU and 72.2% underwent mechanical ventilation. Proteinuria at admission was present in 62.4% of patients and proteinuria during hospital-stay occurred in 37.5%. Those patients with proteinuria at admission had higher burden of comorbidities, higher baseline sCr, and MODS was severe. On the other hand, patients with de novo proteinuria had lower incidence of comorbidities and near normal sCr at admission, but showed adverse course of disease. COVID-19 MODS was the main cause of AKI in both groups. All-cause mortality of the general population was 57.4%, and it was associated to age, sepsis as cause of AKI, severity of condition at admission, oliguria, mechanical ventilation, non-recovery of renal function, in-hospital complications and hospital stay. In conclusion, our study contributes to a better knowledge of this condition and highlights the relevance of the detection of proteinuria throughout the clinical course.
SARS-CoV-2 Vaccination Reduces the Frequency of Acute Kidney Disease in COVID-19 Patients: A Prospective Multicenter Multinational Study
(American Society of Nephrology, 2023) Raúl Lombardi; Alejandro Ferreiro; Joanna Yanissa Venegas Justiniano; Mariana Batista Pereira; M. Carlino; Rolando Claure‐Del Granado; Daniela Ponce; Maria A. Zinoveev