Browsing by Autor "Mario Apata"

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    The genetic prehistory of the Andean highlands 7,000 Years BP though European contact
    (2018) John Lindo; Randall Haas; Courtney A. Hofman; Mario Apata; Mauricio Moraga; Ricardo A. Verdugo; James T. Watson; Carlos Viviano Llave; David Witonsky; Enrique Pacheco
    Abstract The peopling of the Andean highlands above 2500m in elevation was a complex process that included cultural, biological and genetic adaptations. Here we present a time series of ancient whole genomes from the Andes of Peru, dating back to 7,000 calendar years before present (BP), and compare them to 64 new genome-wide genetic variation datasets from both high and lowland populations. We infer three significant features: a split between low and high elevation populations that occurred between 9200-8200 BP; a population collapse after European contact that is significantly more severe in South American lowlanders than in highland populations; and evidence for positive selection at genetic loci related to starch digestion and plausibly pathogen resistance after European contact. Importantly, we do not find selective sweep signals related to known components of the human hypoxia response, which may suggest more complex modes of genetic adaptation to high altitude. One Sentence Summary Ancient DNA from the Andes reveals a complex picture of human adaptation from early settlement to the colonial period.