Browsing by Autor "Marleen Boelaert"

Now showing 1 - 9 of 9

Brote epidémico de denguevirus 2, genotipo Jamaica, en Bolivia
(Instituto Nacional de Salud Pública, 1998) Alberto Gianella; Marianne Pirard; Anaí Holzman; Marleen Boelaert; Frank Fernández-Ortiz; Carlos Peredo; J L Pelegrino; Patrick Van der Stuyft
Objetivo. Confirmar la presencia de brote de dengue en la ciudad de Santa Cruz, Bolivia, así como identificar el denguevirus causal, estimar la tasa de ataque y determinar la proporción de infecciones sintomáticas. Material y métodos. En marzo de 1997 se realizó una encuesta seroepidemiológica con muestreo aleatorio en un distrito céntrico de la ciudad. Se obtuvo información sobre episodios de enfermedad aguda, antecedentes de cuadro febril reciente y muestras de sangre venosa. Se determinó la presencia de IgM antidengue con el método MAC ELISA y se procedió a la tipificación del virus con tecnología de reacción en cadena de la polimerasa. Resultados. Se detectaron anticuerpos IgM en 6.5% de los adultos (IC95% 3.4-9.6) y 5.1% de los niños (IC 95% 2.0-8.2). El virus circulante fue identificado como dengue serotipo 2, genotipo Jamaica. Menos de la mitad de los niños infectados tuvieron una infección sintomática, contra casi 90% de los adultos. Conclusiones. La tasa de ataque estimada es compatible con una epidemia de dengue en Santa Cruz. La introducción del serotipo 2 - Jamaica en el país aumenta el riesgo de dengue hemorrágico.
[Epidemic outbreak of dengue virus 2/Jamaica genotype in Bolivia].
(National Institutes of Health, 1999) Alberto Gianella; M Pirard; Anaí Holzman; Marleen Boelaert; Frank Fernández-Ortiz; Carlos Peredo; Pelegrino Jl; Van der Stuyft P
The estimated attack rates are compatible with a Dengue epidemic outbreak in Santa Cruz. The introduction of the serotype 2/ subgroup Jamaica virus into the country increases the risk of hemorrhagic Dengue.
Generic sodium stibogluconate is as safe and effective as branded meglumine antimoniate, for the treatment of tegumentary leishmaniasis in Isiboro Secure Park, Bolivia
(Maney Publishing, 2006) Harry Bermudez; E. Rojas; Lineth García; P. Desjeux; J.-C. Dujardin; Marleen Boelaert; François Chappuis
Human cutaneous leishmaniasis (CL) and mucous leishmaniasis (ML) are highly endemic in Isiboro Secure Park, which lies in the Bolivian department of Cochabamba--an area where branded meglumine antimoniate (Glucantime) is expensive and poorly distributed. The safety and efficacy of generic sodium stibogluconate (SSG), from Albert David Ltd, was therefore explored, in CL and ML cases from the park, who were treated with 20 mg/kg.day for 20 and 30 days, respectively. A questionnaire recording adverse effects was completed by a physician in each treatment centre. Efficacy of treatment was assessed at the end of treatment and at follow-ups 1 month and 3, 6 and 12 months later. Overall, 146 patients completed treatment with SSG in 2003-2004. No fatalities or severe adverse effects were reported but mild to moderate adverse effects were noted in 41 (28%) of the patients. The incidence of adverse effects was significantly higher among the cases of ML than among the cases of CL. Of the 86 patients with CL who completed 6 months of follow-up, 81 (94.2%) were considered to have been clinically cured; a comparable cohort of 69 CL cases who had been treated with Glucantime in 2001-2002 showed a similar frequency of clinical cure (90%). Generic SSG was shown to be safe and efficacious for the treatment of tegumentary leishmaniasis in Bolivia. Being several times cheaper than Glucantime, it could contribute to improving the access of CL and ML patients to treatment, not only in Bolivia but also in other countries of Latin America.
Incidence of Surgical-Site Infections and the Validity of the National Nosocomial Infections Surveillance System Risk Index in a General Surgical Ward in Santa Cruz, Bolivia
(Cambridge University Press, 2003) Lorena Soleto; Marianne Pirard; Marleen Boelaert; Remberto Peredo; Reinerio Vargas; Alberto Gianella; Patrick Van der Stuyft
SSIs cause considerable morbidity in Santa Cruz. Appropriate nosocomial infection surveillance and control should be introduced. The NNIS System risk index did not discriminate between patients at low and high risk for SSI in this hospital setting, but a risk score based on local cutoff points performed substantially better.
Research Priorities for Neglected Infectious Diseases in Latin America and the Caribbean Region
(Public Library of Science, 2010) Jean‐Claude Dujardin; Sócrates Herrera; Virgilio do Rosario; Jorge Arévalo; Marleen Boelaert; H. Carrasco; Rodrigo Corrêa‐Oliveira; Lineth García; Eduardo Gotuzzo; Theresa W. Gyorkos
Americanae nace como un proyecto conjunto que surge dentro de la Red Europea de Información y Documentación sobre América Latina (REDIAL), y que ha afrontado la Biblioteca de la Agencia Española de Cooperación Internacional para el Desarrollo (AECID). Esta nueva biblioteca virtual hace más accesibles los libros digitales de tema americanista a los investigadores y usuarios interesados de cualquier parte del mundo.
Short communication: Dengue serotype 2 subtype III (‘Jamaica’) epidemic in Santa Cruz, Bolivia
(Wiley, 1998) Van der Stuyft; Gianella; Pirard; Holzman; Peredo; Marleen Boelaert; Vorndam
The estimated attack rates are compatible with a dengue epidemic in Santa Cruz. Isolation of dengue-2 'Jamaica' virus documents the further spread of this subtype from the Caribbean via Brazil into South America. Increased DHF preparedness seems mandatory.
Street Youths Are the Only High-Risk Group for HIV in a Low-Prevalence South American Country
(Lippincott Williams & Wilkins, 2005) Marie‐Laurence Lambert; Faustino Torrico; Claire Billot; Deogatias Mazina; Marleen Boelaert; Patrick Van der Stuyft
In a low-prevalence setting where intravenous drug use is uncommon, street youths are a threat for the expansion of the HIV epidemic. We argue that HIV prevention in this population requires a comprehensive approach to their health and social problems.
The validity of serologic tests for <i>Trypanosoma cruzi</i> and the effectiveness of transfusional screening strategies in a hyperendemic region
(Wiley, 2005) Marianne Pirard; Naomi Iihoshi; Marleen Boelaert; Paulino Basanta; Francisco Gomez Lopez; Patrick Van der Stuyft
Routine blood donor screening for T. cruzi with a single test results in unacceptable numbers of false-negative samples in highly endemic areas or in at risk population groups. Adding a second test seems mandatory, but which one to choose depends on local cost components and feasibility.
Urbanisation of yellow fever in Santa Cr uz, Bolivia
(Elsevier BV, 1999) Patrick Van der Stuyft; Alberto Gianella; M Pirard; Juan Manuel Sánchez Céspedes; Jacyr Lora; Carlos Peredo; Pelegrino Jl; V. Vorndam; Marleen Boelaert