Browsing by Autor "Mathias Dutschmann"

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    Coping with hypoxemia: Could erythropoietin (EPO) be an adjuvant treatment of COVID-19?
    (Elsevier BV, 2020) Jorge Soliz; Edith M. Schneider Gasser; Christian Arias‐Reyes; Fernanda Aliaga‐Raduán; Liliana Poma-Machicao; Gustavo Zubieta‐Calleja; Werner I. Furuya; Pedro Trevizan‐Baú; Rishi R. Dhingra; Mathias Dutschmann
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    Decreased incidence, virus transmission capacity, and severity of COVID-19 at altitude on the American continent
    (2020) Christian Arias‐Reyes; Favio Carvajal-Rodriguez; Liliana Poma-Machicao; Fernanda Aliaga-Raudan; Danuzia A. Marques; Natalia Zubieta DeUrioste; Roberto A. Accinelli; Edith M. Schneider Gasser; Gustavo Zubieta‐Calleja; Mathias Dutschmann
    Abstract The coronavirus disease 2019 (COVID-19) outbreak in North, Central, and South America has become the epicenter of the current pandemic. We have suggested previously that the infection rate of this virus might be lower in people living at high altitude (over 2,500 m) compared to that in the lowlands. Based on data from official sources, we performed a new epidemiological analysis of the development of the pandemic in 23 countries on the American continent as of May 23, 2020. Our results confirm our previous finding, further showing that the incidence of COVID-19 on the American continent decreases significantly starting at 1,000 m above sea level (masl). Moreover, epidemiological modeling indicates that the virus transmission rate capacity is lower in the highlands (>1,000 masl) than in the lowlands (<1,000 masl). Finally, evaluating the differences in the recovery percentage of patients, the death-to-case ratio, and the theoretical fraction of undiagnosed cases, we found that the severity of COVID-19 is also decreased above 1,000 m. We conclude that the impact of the COVID-19 decreases significantly with altitude. Highlights There is a negative correlation between altitude and COVID-19 incidence on the American Continent starting from 1,000 m above sea level. The transmission rate of SARS-CoV-2 is lower in the highlands than in the lowlands. The severity of COVID-19 decreases significantly with increased altitude.
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    Does the pathogenesis of SARS-CoV-2 virus decrease at high-altitude?
    (Elsevier BV, 2020) Christian Arias‐Reyes; Natalia Zubieta-DeUrioste; Liliana Poma-Machicao; Fernanda Aliaga‐Raduán; Favio Carvajal-Rodriguez; Mathias Dutschmann; Edith M. Schneider Gasser; Gustavo Zubieta‐Calleja; Jorge Soliz