Browsing by Autor "Matteo Bassetti"

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    Understanding the pathophysiology of typical acute respiratory distress syndrome and severe COVID-19
    (Taylor & Francis, 2022) Lorenzo Ball; Pedro Leme Silva; Daniele Roberto Giacobbe; Matteo Bassetti; Gustavo Zubieta‐Calleja; Patrícia R. M. Rocco; Paolo Pelosi
    ARDS is defined as a syndrome rather than a distinct pathologic entity. There is great heterogeneity regarding the pathophysiologic, clinical, radiologic, and biological phenotypes in patients with ARDS, challenging clinicians, and scientists to discover new therapies. COVID-19 has been described as a cause of pulmonary ARDS and has reopened many questions regarding the pathophysiology of ARDS itself. COVID-19 lung injury involves direct viral epithelial cell damage and thrombotic and inflammatory reactions. There are some differences between ARDS and COVID-19 lung injury in aspects of aeration distribution, perfusion, and pulmonary vascular responses.