Browsing by Autor "Michel Sauvain"

Now showing 1 - 20 of 40

4-Quinolinone alkaloids from Dictyoloma peruviana
(Elsevier BV, 1995) Catherine Lavaud; Georges Massiot; Carmen Vásquez; Christian Moretti; Michel Sauvain; Luisa Balderrama
A NEW ANTHRAQUINONE ISOLATED FROM RUMEX OBTUSIFOLIUS
(Universidad Autónoma del Estado de México, 2009) Sandra L. Ibáñez-Calero; Valérie Jullian; Michel Sauvain
"In this research we studied Rumex obtusifolius (Polygonaceae) along with other plants used in traditional medicine in relation to the chemical reaction FBIT (Ferriprotoporphyrine Biocrystallization Inhibition Test) which may provide information on a possible action mechanism for presumed antimalarial plants. According to folk medicine Rumex obtusifolius has a pronounced detoxifying effect on the liver and is used against jaundice and fever. Following a chemical reaction-guided isolation on Rumex obtusifolius we obtained demethylmacrosporine I, an anthraquinone derivative. Its structural determination by one and two dimensional NMR and a proposition of structure-activity relationship are presented."
A New Diterpene from Tanaecium jaroba
(Thieme Medical Publishers (Germany), 2002) Anne‐Claire Mitaine‐Offer; Michel Sauvain; Eric Deharo; Victoria Muñoz; Monique Zèches-Hanrot
One new diterpene, 2 alpha-hydroxy-12beta-hydroxy-isopimara-8(14), 15-diene, and six known compounds as triterpenes, sterols and fatty acid, were isolated from the stem bark of Tanaecium jaroba (Bignoniaceae), a Bolivian plant used in traditional medicine. Their structures were established mainly by 1D and 2D NMR (COSY, HMQC, HMBC, ROESY) and their antiplasmodial activities were evaluated in vitro against Plasmodium falciparum.
A non-radiolabelled ferriprotoporphyrin IX biomineralisation inhibition test for the high throughput screening of antimalarial compounds
(Elsevier BV, 2002) Eric Deharo; Rory Nelson García; P Oporto; A. Giménez; Michel Sauvain; Valérie Jullian; H. Ginsburg
A Novel Antiprotozoal Aminosteroid from Saracha punctata
(American Chemical Society, 1998) Christian Moretti; Michel Sauvain; Catherine Lavaud; Georges Massiot; José A. Bravo; Verónica Francisca Loewe Muñoz
A new aminosteroid, 3beta-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-beta-D-glucopyranosyl-eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 microM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 microM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.
A search for natural bioactive compounds in Bolivia through a multidisciplinary approach
(Elsevier BV, 2000) Verónica Francisca Loewe Muñoz; Michel Sauvain; Geneviève Bourdy; S Arrázola; Jorgia Callapa; Grace Ruiz; J Choque; Eric Deharo
A search for natural bioactive compounds in Bolivia through a multidisciplinary approach
(Elsevier BV, 2000) R. Baelmans; Eric Deharo; Geneviève Bourdy; Verónica Francisca Loewe Muñoz; C. Quenevo; Michel Sauvain; H. Ginsburg
A search for natural bioactive compounds in Bolivia through a multidisciplinary approach
(Elsevier BV, 2000) Verónica Francisca Loewe Muñoz; Michel Sauvain; Geneviève Bourdy; Jorgia Callapa; S. Bergeron; Irma Torres Rojas; José A. Bravo; Luisa Balderrama; B. Ortiz; A. Giménez
A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part V. Evaluation of the antimalarial activity of plants used by the Tacana Indians
(Elsevier BV, 2001) Eric Deharo; Geneviève Bourdy; C. Quenevo; Verónica Francisca Loewe Muñoz; Grace Ruiz; Michel Sauvain
A study of the chemical composition of Erythroxylum coca var. coca leaves collected in two ecological regions of Bolivia
(Elsevier BV, 1997) Michel Sauvain; C Rerat; Christian Moretti; E. Saravia; S. Arrazola; Eusebio Dohijo Gutiérrez; Ana María Lema; Verónica Francisca Loewe Muñoz
Actividad antipalúdica y potenciación de la cloroquina con alcaloides aporfínicos in vitro
(2001) Muñoz; Michel Sauvain; André Fournet; Bernard Weniger; A. Valentín; M. Mallié; Jorgia Callapa; Eric Deharo; Pierre‐Marie Duret
Activité antipaludique du n-hentriacontanol isolé deCuatresiasp (Solanaceae)
(EDP Sciences, 1992) Eric Deharo; Michel Sauvain; Costanzo Moretti; Bernard Richard; E. Ruiz; Georges Massiot
L’activité antipaludique de l’alcool gras n-hentriacontanol isolé d’une Solanacée bolivienne Cuatresia sp. est appréciée in vivo, par le test classique du traitement de 4 jours, sur Plasmodium berghei et P. vinckei chez la souris. Le produit réduit nettement la virulence de l’infection à P. vinckei. Le n-hentriacontanol appartient à une nouvelle classe de composés naturels antimalariques exploitables en thérapeutique.
Anti-infective assessment of Senecio smithioides (Asteraceae) and isolation of 9-oxoeuryopsin, a furanoeremophilane-type sesquiterpene with antiplasmodial activity
(Taylor & Francis, 2015) Patricia Mollinedo; José L. Vila; Hugo Arando; Michel Sauvain; Eric Deharo; José A. Bravo
The search for anti-infective activity in the antipyretic plant Senecio smithioides was conducted. Petroleum ether (PE), dichloromethane (CH2Cl2), ethyl acetate (EtOAc) and hydroethanolic (96% EtOH) extracts, and compounds 9-oxoeuryopsin (1), epoxydecompostin (2) and senecionine (3) were obtained from the aerial parts. All extracts and 1 were tested against chloroquine-resistant strain of Plasmodium falciparum (ref. chloroquine), Trypanosoma cruzi (ref. nifurtimox), Leishmania braziliensis, Leishmania amazonensis and Leishmania donovani (ref. pentamidine), Staphylococcus aureus and Escherichia coli (ref. gentamicin) and, Neurospora crassa and Candida albicans (ref. ketoconazole). The PE extract exhibited the strongest in vitro activity against Plasmodium falciparum IC50 < 1.0 μg/mL. 1 was established as a potent antiplasmodial compound with an IC50 = 1.2 μg/mL, 5.2 μM. Other antiparasitic activities were recorded for all extracts and 1. Antibacterial and antifungal activity was negligible.
Anti-Leishmanial Lindenane Sesquiterpenes fromHedyosmum angustifolium
(Thieme Medical Publishers (Germany), 2009) Lucia Acebey; Valérie Jullian; Denis Séréno; Séverine Chevalley; Yannick Estevez; Claude Moulis; Stephan Beck; Alexis Valentin; Alberto Giménez; Michel Sauvain
The aim of this work is the isolation of anti-leishmanial compounds from the ethyl acetate extracts of the bark of HEDYOSMUM ANGUSTIFOLIUM. We have successfully isolated and characterized five sesquiterpenes: one new compound (oxyonoseriolide, 1), one compound isolated for the first time from a natural source (hedyosmone, 2), and three known sesquiterpenes (onoseriolide, 3; chloranthalactone A, 4; and spathulenol, 5) that had not been previously isolated from H. ANGUSTIFOLIUM. The biological activities of 1- 5 showed that onoseriolide ( 3) was the most active compound against axenic amastigotes from LEISHMANIA AMAZONENSIS and L. INFANTUM. Moreover, it was still active on the intramacrophagic amastigotes of L. INFANTUM. The isolated compounds have also been tested on PLASMODIUM FALCIPARUM and against various mammalian cell lines.
Antimalarial Activity and Cytotoxicity of (-)-Roemrefidine Isolated from the Stem Bark ofSparattanthelium amazonum
(Thieme Medical Publishers (Germany), 1999) Verónica Francisca Loewe Muñoz; Michel Sauvain; Patricia Mollinedo; Jorgia Callapa; I. Gina Rojas; A. Giménez; Alexis Valentin; M. Mallié
(-)-Roemrefidine, an aporphine alkaloid isolated from Sparattanthelium amazonum Martius (Hernandiaceae) a vine from Bolivia, has been found to be active against both resistant and sensitive strains of Plasmodium falciparum in vitro and against P. berghei in mice. The compound demonstrated no cytotoxic activity against three cell lines (KB, HEp-2 and HeLa).
Antimalarial Activity of Alkaloids from Pogonopus tubulosus
(Wiley, 1996) Michel Sauvain; Christian Moretti; José-Antonio Bravo; Jorgia Callapa; Victoria Muñoz; E. Ruiz; Bernard Richard; Louisette Le Men‐Olivier
The antimalarial activity of the Bolivian medicinal plant Pogonopus tubulosus (D.C.) Schumann was evaluated by in vitro testing on trophozoite stages of resistant and sensitive strains of Plasmodium falciparum and by in vivo tests on P. berghei and P. vinckei petteri in mice. The bark of this medicinal plant yielded three alkaloids: tubulosine, psychotrine, cephaeline. Tubulosine showed an interesting activity in vitro with an IC50 of 0.006 μg/mL against the sensitive strain of P. falciparum and an IC50 of 0.011 μg/mL against the resistant strain of P. falciparum. This compound had good in vivo antimalarial activity with an ED50 of 0.05 mg/kg/day on P. vinckei petteri strain and an ED50 of 0.45 mg/kg/day on P. berghei.
Antimalarial Activity of Alkaloids fromPogonopus tubulosus
(Wiley, 1996) Michel Sauvain; Christian Moretti; José-Antonio Bravo; Jorgia Callapa; Victoria Muñoz; E. Ruiz; Bernard Richard; Louisette Le Men‐Olivier
The antimalarial activity of the Bolivian medicinal plant Pogonopus tubulosus (D.C.) Schumann was evaluated by in vitro testing on trophozoite stages of resistant and sensitive strains of Plasmodium falciparum and by in vivo tests on P. berghei and P. vinckei petteri in mice. The bark of this medicinal plant yielded three alkaloids: tubulosine, psychotrine, cephaeline. Tubulosine showed an interesting activity in vitro with an IC50 of 0.006 μg/mL against the sensitive strain of P. falciparum and an IC50 of 0.011 μg/mL against the resistant strain of P. falciparum. This compound had good in vivo antimalarial activity with an ED50 of 0.05 mg/kg/day on P. vinckei petteri strain and an ED50 of 0.45 mg/kg/day on P. berghei.
Antimalarial activity of cedronin
(Elsevier BV, 1994) Christian Moretti; Eric Deharo; Michel Sauvain; Claude Jardel; Pedroza-Escobar David; M. Gasquet
Antiplasmodial activity of Aspidosperma indole alkaloids
(Elsevier BV, 2002) Anne‐Claire Mitaine‐Offer; Michel Sauvain; Alexis Valentin; Jorgia Callapa; M. Mallié; Monique Zèches-Hanrot
Antiprotozoal activity of Jatrogrossidione from Jatropha grossidentata and Jatrophone from Jatropha isabellii 
(Wiley, 1996) Guillermo Schmeda‐Hirschmann; Iván Razmilic; Michel Sauvain; Christian Moretti; Verónica Francisca Loewe Muñoz; E. Ruiz; Elfride Balanza; Alain Fournet
The activity of jatrogrossidione, the main diterpene of Jatropha grossidentata and jatrophone from Jatropha isabellii was determined against Leishmania and Trypanosoma cruzi strains in vitro as well as against Leishmania amazonensis in vivo. Jatrogrossidione showed a strong in vitro leishmanicidal and trypanocidal activity with IC100 of 0.75 and 1.5–5.0 μg/mL, respectively. Under similar conditions, the IC100 of glucantime, ketoconazole and pentamidine towards Leishmania strains were >100, 50–100 and 1 μg/mL, respectively. The IC50 of jatrogrossidione was <0.25 μg/mL against amastigote forms of Leishmania infecting macrophages, with toxicity at concentrations higher than 0.5 μg/mL. BALB/c mice infected with L. amazonensis strain PH 8 were treated 24 h after infection with jatrogrossidione and jatrophone for 13 consecutive days. Jatrophone at 25 mg/kg/day subcutaneously administered was significantly active (p<0.05) against the virulent strain PH 8 of L. amazonesis; it was more active than Glucantime at 112 mg Sbv per kg/day. Subcutaneous administration of jatrophone, however, proved to be too toxic under our assay conditions. Assays of single local treatment on the footpad infection 2 weeks after inoculation of L. amazonensis indicated that jatrogrossidione and jatrophone were inactive at the selected doses.