Browsing by Autor "Mostajo-Radji, Mohammed A."

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Cambiando la Identidad celular para crear una verdadera medicina personalizada
(Gac Med Bol, 2012) Mostajo-Radji, Mohammed A.; M.R. Ferreira, Leonardo
El Premio Nobel 2012 en Fisiología o Medicina fue concedido a Sir John Gurdon y Shinya Yamanaka por sus avances en la reprogramación celular. Estos descubrimientos no sólo cambiaron nuestra visión del proceso de diferenciación celular, pero también tienen el potencial de revolucionar la medicina. Proporcionando una breve contextualización histórica y un resumen sucinto de las metodologías actuales, presentamos los principales avances en la investigación básica, así como sus posibles aplicaciones en la clínica. Esta revisión tiene como objetivo proporcionar un panorama general del estado actual sobre el campo de reprogramacióncelular y sus implicaciones terapéuticas.
Cloud-controlled microscopy enables remote project-based biology education in underserved Latinx communities
(2024) Montellano Duran, Natalia; Baudin, Pierre V.; Sacksteder, Raina E.; Worthington, Atesh K.; Voitiuk, Kateryna; T. Ly, Victoria; Hoffman, Ryan N.; Elliott, Matthew A.T.; Parks, David F.; Ward, Rebecca; Torres-Montoya, Sebastian; Amend, Finn; Vargas, Paola A.; Martinez, Guadalupe; Ramirez, Sandra M.; Alvarado-Arnez, Lucia Elena; Ehrlich, Drew; Rosen, Yohei M.; Breevoort, Arnar; Schouten, Tallulah; Kurniawan, Sri; Haussler, David; Mostajo-Radji, Mohammed A.
https://www.cell.com/action/showPdf?pii=S2405-8440%2822%2902884-5 | Project-based learning (PBL) has long been recognized as an effective way to teach complex biology concepts. However, not all institutions have the resources to facilitate effective project-based coursework for students. We have developed a framework for facilitating PBL using remote-controlled internet-connected microscopes. Through this approach, one lab facility can host an experiment for many students around the world simultaneously. Experiments on this platform can be run on long timescales and with materials that are typically unavailable to high school classrooms. This allows students to perform novel research projects rather than just repeating standard classroom experiments. To investigate the impact of this program, we designed and ran six user studies with students worldwide. All experiments were hosted in Santa Cruz and San Francisco, California, with observations and decisions made remotely by the students using their personal computers and cellphones. In surveys gathered after the experiments, students reported increased excitement for science and a greater desire to pursue a career in STEM. This framework represents a novel, scalable, and effective PBL approach that has the potential to democratize biology and STEM education around the world.
Open-loop lab-on-a-chip technology enables remote computer science training in Latinx life sciences students
(2025) Sano, Tyler; Neyen Sampad, Mohammad Julker; Gonzalez-Ferrer, Jesus; Hernandez, Sebastian; Vera-Choqqueccota, Samira; Vargas, Paola A.; Urcuyo, Roberto; Montellano Duran, Natalia; Teodorescu, Mircea; Haussler, David; Schmidt, Holger; Mostajo-Radji, Mohammed A.
https://www.biorxiv.org/content/10.1101/2023.04.28.538776v1 | Despite many interventions, science education remains highly inequitable throughout the world. Among all life sciences fields, Bioinformatics and Computational Biology suffer from the strongest underrepresentation of racial and gender minorities. Internet-enabled project-based learning (PBL) has the potential to reach underserved communities and increase the diversity of the scientific workforce. Here, we demonstrate the use of lab-on-a-chip (LoC) technologies to train Latinx life science undergraduate students in concepts of computer programming by taking advantage of open-loop cloud- integrated LoCs. We developed a context-aware curriculum to train students at over 8,000 km from the experimental site. We showed that this approach was sufficient to develop programming skills and increase the interest of students in continuing careers in Bioinformatics. Altogether, we conclude that LoC-based Internet-enabled PBL can become a powerful tool to train Latinx students and increase the diversity in STEM.