Browsing by Autor "Nguyen Tien Huy"

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    Knowledge, behaviour and attitudes towards Chagas disease among the Bolivian migrant population living in Japan: a cross-sectional study
    (BMJ, 2020) Inés María Iglesias Rodríguez; Shusaku Mizukami; Đào Huy Mạnh; Thuan Minh Tieu; Hugo Alberto Justiniano; Sachio Miura; George Ito; Nguyen Tien Huy; Chris Smith; Kenji Hirayama
    EA with an integrative approach is useful to increase the knowledge of CD within the Bolivian migrant population living in Japan. The activity brings the possibility to explore not only the level of knowledge but also to reveal experiences and to understand the needs of the people at risk. Considering them as actors towards healthcare solutions could lead to better outcomes for the success of future policies and interventions aimed to decrease the global burden.
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    Proteomic profile of circulating immune complexes in chronic Chagas disease
    (Wiley, 2016) Kaname Ohyama; Nguyen Tien Huy; Hiroki Yoshimi; Naoya Kishikawa; Juan Eiki Nishizawa; Yelin Roca; R. J. Revollo Guzmán; Freddy Udalrico Gutierrez Velarde; Naotaka Kuroda; Kenji Hirayama
    Immune complexes (ICs) are the direct and real-time products of humoral immune responses. The identification of constituent foreign or autoantigens within ICs might bring new insights into the pathology of infectious diseases. We applied immune complexome analysis of plasma to the study of Chagas disease caused by Trypanosoma cruzi. Twenty seropositive plasma samples including cardiac and/or megacolon determinate patients (n = 11) and indeterminate (n = 9) were analysed along with 10 seronegative individuals to characterize the antigens bound to circulating ICs. We identified 39 T. cruzi antigens and 114 human autoantigens specific to patients with Chagas. Among those antigens, two T. cruzi antigens (surface protease GP63, glucose-6-isomerase) and six human autoantigens (CD180 antigen, ceruloplasmin, fibrinogen beta chain, fibrinogen beta chain isoform 2 preprotein, isoform gamma-A of fibrinogen γ-chain, serum paraoxonase) were detected in more than 50% of the patients tested. Human isoform short of complement factor H-related protein 2 and trans-sialidase of T. cruzi were more frequently found in the indeterminate (5/9 for both) compared with in the determinate Chagas (0/11, P = 0·046 for human, 1/11, P = 0·0498 for T. cruzi). The immune complexome could illustrate the difference of immune status between clinical forms of chronic Chagas disease.