Browsing by Autor "Nicolas Tebib"

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Prevalence and Risk Factors of Strongyloides stercoralis in Haemodialysis in Cochabamba, Bolivia: A Cross-Sectional Study
(Research Square (United States), 2022) Nicolas Tebib; Nathalie Tebib; Mauricio Paredes; Rosario Castro; Stéphanie Baggio; Mario Villarroel Torrico; Amilcar Alejandro Flores Leon; Maya Herbas Zamorano; François Chappuis; Laurent Gétaz
Abstract Background: Strongyloidiasis is an infectious disease that can be fatal in immunocompromised patients. Patients with end-stage renal failure who are on dialysis have a considerably weakened immune system, and kidney transplantation is a major risk factor for severe strongyloidiasis. Knowledge of the local epidemiology in tropical and subtropical areas is an essential prerequisite for designing an appropriate strategy to prevent this potentially lethal complication. In this study, we aimed to estimate the prevalence and associated risk factors of S. stercoralis infection in patients on dialysis in Cochabamba, Bolivia. Methods: A cross-sectional study was carried out among patients undergoing haemodialysis in Cochabamba (elevation 2,500 metres, temperate climate), collecting information on socio-demographic, lifestyle, and clinical variables, and using one coproparasitological technique (the modified Baermann technique) and one serological (ELISA) test. Results: In total, 149 patients participated in the study (mean age = 51.4 years, 48.3% male). End-stage renal disease was predominantly (59%) of hypertensive and/or diabetic origin. The positive serological prevalence was 18.8% (95% CI: 13.3%–25.9%). Based on the sensitivity and specificity of the ELISA test, the estimate of the true prevalence was 15.1% (95% CI: 9.4%–20.7%). Stool samples of 105 patients (70.5%) showed a coproparasitological prevalence of 1.9% (95% CI: 0.52%–6.68%). No potential risk factors were significantly associated with S. stercoralis infection. Conclusions: We found a high prevalence of S. stercoralis in Bolivian patients undergoing haemodialysis in Cochabamba. We recommend presumptive antiparasitic treatment at regular intervals to avoid the potentially fatal complications of severe strongyloidiasis.
Prevalence and risk factors of Strongyloides stercoralis in haemodialysis in Cochabamba, Bolivia: a cross-sectional study
(BioMed Central, 2023) Nicolas Tebib; Nathalie Tebib; Mauricio Paredes; Rosario Castro; Stéphanie Baggio; Mario Villarroel Torrico; Amilcar Alejandro Flores Leon; Maya Herbas Zamorano; François Chappuis; Laurent Gétaz