Browsing by Autor "Nicole Phillips"

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    <i>APOE</i> and Alzheimer's disease and related dementias risk among 12,221 Hispanics/Latinos
    (Wiley, 2025) Sandra Barral; Zikun Yang; Nicole Phillips; Robert C. Barber; Adam M. Brickman; Lawrence S. Honig; Basilio Cieza; Dolly Reyes‐Dumeyer; Richard Mayeux; Farid Rajabli
    The apolipoprotein E (APOE) ε4 effect is stronger in Peruvians/Bolivians than in other Hispanic/Latino groups. The strong APOE effect size in Peruvians and Bolivians was replicated in a second independent Peruvian cohort. Meta-analysis for ε4 and ε2 confirmed a significant association with Alzheimer's disease and related dementias (ADRD). Global and local ancestry do not modify the association between APOE genotype and ADRD.