Browsing by Autor "Nilton Custodio"

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A task force for diagnosis and treatment of people with Alzheimer’s disease in Latin America
(Frontiers Media, 2023) Francisco Lopera; Nilton Custodio; Mariana Rico-Restrepo; Ricardo Allegri; José Domingo Barrientos; Estuardo Garcia Batres; Ismael Luis Calandri; Cristian Moscoso; Paulo Caramelli; Juan Carlos Quiroz
Alzheimer's disease (AD) represents a substantial burden to patients, their caregivers, health systems, and society in Latin America and the Caribbean (LAC). This impact is exacerbated by limited access to diagnosis, specialized care, and therapies for AD within and among nations. The region has varied geographic, ethnic, cultural, and economic conditions, which create unique challenges to AD diagnosis and management. To address these issues, the Americas Health Foundation convened a panel of eight neurologists, geriatricians, and psychiatrists from Argentina, Brazil, Colombia, Ecuador, Guatemala, Mexico, and Peru who are experts in AD for a three-day virtual meeting to discuss best practices for AD diagnosis and treatment in LAC and create a manuscript offering recommendations to address identified barriers. In LAC, several barriers hamper diagnosing and treating people with dementia. These barriers include access to healthcare, fragmented healthcare systems, limited research funding, unstandardized diagnosis and treatment, genetic heterogeneity, and varying social determinants of health. Additional training for physicians and other healthcare workers at the primary care level, region-specific or adequately adapted cognitive tests, increased public healthcare insurance coverage of testing and treatment, and dedicated search strategies to detect populations with gene variants associated with AD are among the recommendations to improve the landscape of AD.
Assessing Cognitive Impairment in Quechua and Aymara Patients: A Critical Examination of the Rowland Universal Dementia Assessment Scale’s Discriminative Capacity
(Wiley, 2024) Marco Málaga; Diego Bustamante‐Paytan; Arturo Jhonny Ruiz‐Yaringaño; Belén Custodio; Marcio F. Soto‐Añari; Maria Fernanda Ore‐Gomez; Juan Carlos Quiroz; María Isabel Cusicanqui; Rosa Montesinos; Nilton Custodio
The use of the RUDAS in native language speakers and its ability to distinguish between Mild Cognitive Impairment (MCI) and dementia raise some concerns. To improve assessments for various communities in Latin America and the Caribbean, there is a need for culturally adapted brief cognitive tests.
Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research
(Frontiers Media, 2021) Jorge J. Llibre‐Guerra; María Isabel Behrens; Mirna Lie Hosogi; Lucía Montero; Teresa Torralva; Nilton Custodio; Erika Mariana Longoria-Ibarrola; Margarita Giraldo‐Chica; David Aguillón; Angela Hardi
Introduction: The historical development, frequency, and impact of frontotemporal dementia (FTD) are less clear in Latin America than in high-income countries. Although there is a growing number of dementia studies in Latin America, little is known collectively about FTD prevalence studies by country, clinical heterogeneity, risk factors, and genetics in Latin American countries. Methods: A systematic review was completed, aimed at identifying the frequency, clinical heterogeneity, and genetics studies of FTD in Latin American populations. The search strategies used a combination of standardized terms for FTD and related disorders. In addition, at least one author per Latin American country summarized the available literature. Collaborative or regional studies were reviewed during consensus meetings. Results: The first FTD reports published in Latin America were mostly case reports. The last two decades marked a substantial increase in the number of FTD research in Latin American countries. Brazil (165), Argentina (84), Colombia (26), and Chile (23) are the countries with the larger numbers of FTD published studies. Most of the research has focused on clinical and neuropsychological features (n = 247), including the local adaptation of neuropsychological and behavioral assessment batteries. However, there are little to no large studies on prevalence (n = 4), biomarkers (n = 9), or neuropathology (n = 3) of FTD. Conclusions: Future FTD studies will be required in Latin America, albeit with a greater emphasis on clinical diagnosis, genetics, biomarkers, and neuropathological studies. Regional and country-level efforts should seek better estimations of the prevalence, incidence, and economic impact of FTD syndromes.