Browsing by Autor "Nora Medrano-Mercado"

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    An Updated Insight into the Sialotranscriptome of Triatoma infestans: Developmental Stage and Geographic Variations
    (Public Library of Science, 2014) Alexandra Schwarz; Nora Medrano-Mercado; Günter A. Schaub; Claúdio J. Struchiner; M. Dolores Bargues; Michael Z. Levy; José M. C. Ribeiro
    Over five thousand CDS, mostly full length or near full length, were publicly deposited on GenBank. Transcripts that were over 10-fold overexpressed from different geographical regions, or from different developmental stages were identified. Polymorphisms were mapped to derived coding sequences, and found to vary between developmental instars and geographic origin of the biological material. This expanded sialome database from T. infestans should be of assistance in future proteomic work attempting to identify salivary proteins that might be used as epidemiological markers of vector exposure, or proteins of pharmacological interest.
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    Antibody responses of domestic animals to salivary antigens of Triatoma infestans as biomarkers for low-level infestation of triatomines
    (Elsevier BV, 2009) Alexandra Schwarz; J. Sternberg; Valerie Johnston; Nora Medrano-Mercado; Jennifer M. Anderson; Jen C. C. Hume; Jesús G. Valenzuela; Günter A. Schaub; Peter F. Billingsley
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    Current prevalence and risk factors related to Chagas disease in Bolivia
    (Universidad Católica de Oriente, 2019) Nora Medrano-Mercado; Tania Alba Medrano; G x FC nter A. Schaub; Edmundo C. Grisard; Mário Steindel
    Chagas disease (CD) caused by Trypanosoma cruzi, is a major health problem in Bolivia. In this study, we have assessed the prevalence and the risk of infection by T. cruzi in nine Bolivian departments. The overall average seroprevalence was 19.5% (2-32%) being higher in women between 11-20 years old. The T.cruzi genetic lineages infecting humans was 43.4% TcI; 45.4% TcV, 8.5% TcII and 2.7% for TcV and TcII. T. cruzi infection was detected in 49.1% of the 1,671 Triatoma infestans captured within houses, the majority (65%) made of bricks. Among these, 39.5% were TcI, 52.1% TcV, and 8.4% TcII. The assessment on the knowledge about the disease and the etiological agent revealed that 57% of teachers and health workers are aware of the parasite and 64% of the students receive information about CD, among which, 82% were able to recognize triatomines.
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    IgM-antibody responses of chickens to salivary antigens of Triatoma infestans as early biomarkers for low-level infestation of triatomines
    (Elsevier BV, 2010) Alexandra Schwarz; Nora Medrano-Mercado; Peter F. Billingsley; Günter A. Schaub; J. Sternberg
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    Immunogenic Salivary Proteins of Triatoma infestans: Development of a Recombinant Antigen for the Detection of Low-Level Infestation of Triatomines
    (Public Library of Science, 2009) Alexandra Schwarz; Stefan Helling; Nicolas Collin; Clarissa Teixeira; Nora Medrano-Mercado; Jen C. C. Hume; Teresa C. F. Assumpção; Katrin Marcus; Christoph Stephan; Helmut E. Meyer
    The recombinant rTiSP14.6 is a suitable and promising epidemiological marker for detecting the presence of small numbers of different species of triatomines and could be developed for use as a new tool in surveillance programs, especially to corroborate vector elimination in Chagas disease vector control campaigns.