Browsing by Autor "Nubia Silva"

Now showing 1 - 2 of 2

Epidemiological and clinical characteristics of patients with malaria admitted to a hospital in Mérida, Venezuela
(Oxford University Press, 2019) Juan Carlos Gabaldón-Figueira; Siham Salmen; Nubia Silva; Betania Mancilla; Silvana Vielma
Twenty-two patients were from the Zulia state and eleven were from the Mérida state, mainly from the lowlands south of Lake Maracaibo. Six of these patients traveled to the Bolívar state between 2017 and 2019. Thirteen patients presented with the WHO criteria for severe malaria.Conclusions:Domestic migration to the southeast of Venezuela may have played an important role in the expansion of malaria in previously existing endemic areas of transmission and also in the increase in the number of cases of severe malaria.
Inmunodeficiencias primarias: inmunopatogenia, infecciones asociadas y estrategias terapéuticas
(Universidad Internacional de La Rioja, 2013) Siham Salmen; Rima Bahsas Zaky; Nubia Silva; Luisa Barboza; Guillermo Terán Ángel; Lisbeth Berrueta; Raian Contreras Cardone; Astrid Cantor Garcia; Fabiola Silva; Yanett Guzman Escalona
Primary immunodeficiencies disorders (PID) are a group of genetic defects that affect both innate and adaptive immune response. PID are associated with: 1) absence of cellular components, 2) impaired connection among components of the immune response, as well as in the recognition of foreign, self or modified antigens, and 3) inappropriate modulation of effectors mechanisms either by inability to reach affected tissues, to promote proinflammatory and regulatory polarization, or perform the clearance of invading agents. PID not only increases the susceptibility to infections by different microorganisms, but also alters the homeostatic mechanisms and immune surveillance, that prevent autoinflammatory and neoplastic diseases. This review describes some of these defects, its consequences and the initial approach to the study and management of recurrent infections.