Browsing by Autor "Paola Coral-Alvarado"

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Association of Obesity With Lower Rates of Remission in a Colombian Cohort of Patients With Rheumatoid Arthritis
(Lippincott Williams & Wilkins, 2020) Jorge Bruce Flórez-Suárez; Paul Méndez-Patarroyo; Paola Coral-Alvarado; Gerardo Quintana‐López
Patients with initial obesity were less likely to achieve remission compared with patients with initial overweight or normal weight. Sex and age affects disease activity and BMI variation.
Economic Evaluations in Systemic Lupus Erythematosus
(2011) Gerardo Quintana; Helena Avella; Paola Coral-Alvarado
This chapter shows a historical description of approaches to economic evaluation in SLE, both at national and international framework and highlighting the main elements that must be considered in clinical practice and decisions to avoid increasing the economic burden of health care. A non-systematic review of all published literature in English, French and Spanish from 1990 to April 2011 was performed using Medline, Pubmed, Cochrane, Lilacs and Scielo in peer-reviewed articles, including the Mesh-terms of systemic lupus erythematosus, direct costs, indirect and intangible cost, economic impact, disease burden, Cost-of-illness (COI) studies, pharmacoeconomics analysis, cost-effectiveness and costutility. It will have three types of approaches: the economic impact of the disease, COI studies and finally, a complete pharmacoeconomic assessment.
Pan-American League of Associations for Rheumatology (PANLAR) capillaroscopy study group consensus for the format and content of the report in capillaroscopy in rheumatology
(Springer Science+Business Media, 2019) Chiara Bertolazzi; Angélica Vargas Guerrero; Tatiana Sofia Rodrı́guez-Reyna; Hugo Sandoval; Everardo Álvarez‐Hernández; Marcelo Audisio; E Villamil Cabello; Paola Coral-Alvarado; E. Sifuentes Diaz; Virginia Duringan
Using Proteomic Analysis for Studying the Skin Fibroblast Protein Profile in Systemic Sclerosis
(2012) Paola Coral-Alvarado; G. Quintana; Carmen Lucía Niño Cardozo; J. Iriarte; Yolanda Sánchez; Scarleth Bravo; Justo P. Castaño; María Fernanda Garcés; Libia A. Cepeda; Antonio Iglesias Gamarra
Increased efforts have been made during the last few decades to develop new technologies capable of identifying and quantifying the expression proteome in different cellular systems in physiological and physiopathological conditions for determining illness biomarkers, pharmaceutical targets and/or posttranslational modifications (PTM) by means of proteomic techniques. 2D gel electrophoresis, with immobilized pH gradients, associated with mass spectrometry, is one of the fundamentals steps in studying proteomics. The 2D technique can be used in studying the quantitative expression of protein profiles according to iso-electric point (Ip), molecular weight (Mr), protein solubility and the relative abundance of the above. This methodology provides a protein profile reflecting changes in protein expression levels, isoforms and PTM. Proteins can be classified into those known by their structure and function, those recognized by determined domains and about which there is some knowledge, and those whose function is still not known. Proteomics is defined as the large-scale study of proteins expressed for a specific tissue from a genome, (global proteomics) or differentially expressed proteins (differential proteomics). Determining differentially expressed proteins, or proteins suffering a change in physiological circumstances, is the clue to understanding such pathology’s cellular mechanisms. Although an expressed gene in specific tissues (as an answer to biologic alterations) could be analyzed by a mRNA expression study (transcriptomics), these results do not always coincide with the expected expression profiles since the number and activity of proteins associated with the same regulation in different stages could be modified. Genomic data integration is required, as well as transcritomics,
Vaccination Recommendations for Adults With Autoimmune Inflammatory Rheumatic Diseases in Latin America
(Lippincott Williams & Wilkins, 2017) Claiton Viegas Brenol; Valderílio Feijó Azevedo; Pablo Bonvehí; Paola Coral-Alvarado; Julio Granados; Roberto Muñoz-Louis; Carlos Pineda; Carla Vizzotti
During the conference, each response was edited by the entire group, through numerous drafts and rounds of discussion until a complete consensus on vaccination recommendations for adult patients with AIRDs was obtained, including 7 key recommendations.