Browsing by Autor "Paola Mariela Saba Villarroel"

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A clinical, aetiological, and public health perspective on central nervous system infections in Bolivia, 2017–2018
(Nature Portfolio, 2021) Paola Mariela Saba Villarroel; María del Rosario Castro Soto; Oriana Melendres Flores; Alejandro Peralta Landívar; María E. Calderón; Roxana Loayza; José Boucraut; Laurence Thirion; Audrey Dubot‐Pérès; Läétitia Ninove
Combination of ELISA screening and seroneutralisation tests to expedite Zika virus seroprevalence studies
(BioMed Central, 2018) Elif Nurtop; Paola Mariela Saba Villarroel; Boris Pastorino; Läétitia Ninove; Jan Felix Drexler; Yelin Roca; Bouba Gaké; Audrey Dubot‐Pérès; Gilda Grard; Christophe N. Peyrefitte
Correction to: Combination of ELISA screening and seroneutralisation tests to expedite Zika virus seroprevalence studies
(BioMed Central, 2019) Elif Nurtop; Paola Mariela Saba Villarroel; Boris Pastorino; Läétitia Ninove; Jan Felix Drexler; Yelin Roca; Bouba Gaké; Audrey Dubot‐Pérès; Gilda Grard; Christophe N. Peyrefitte
Dengue virus outbreak in Cochabamba, Bolivia
(2025) Paola Mariela Saba Villarroel; S. SEN; Raphaëlle Klitting; Laura Pezzı; Géraldine Piorkowski; Norma Villavicencio Siles; Sineewanlaya Wichit
Abstract With Aedes aegypti expanding to higher altitudes, dengue virus (DENV) cases soared to record levels in 2024 in Cochabamba, Bolivia (2,558 meters above sea level). Using genome sequencing, we identified at least two distinct clades of DENV-2 genotype II circulating during the outbreak.
Emergence of dengue at high altitude: characterization of the 2024 outbreak in Cochabamba, Bolivia
(BioMed Central, 2026) Paola Mariela Saba Villarroel; S. SEN; Raphaëlle Klitting; Laura Pezzi; Geraldine Piorkowski; Norma Villavicencio Siles; Sineewanlaya Wichit
Dengue virus (DENV) transmission in Bolivia has historically been restricted to tropical lowland regions, where the primary vector Ae. aegypti is endemic. In recent years, however, the vector has expanded into high-altitude areas. In 2024, Cochabamba, located at ~ 2,550 m above sea level, experienced its largest recorded dengue outbreak. We analyzed data from 9,576 suspected dengue cases reported between January and July 2024, of which 5,923 were laboratory-confirmed. A subset of DENV-positive samples underwent whole-genome sequencing and phylogenetic analysis. Dengue cases were detected in municipalities located at elevations up to 2,719 m, with the highest number reported in Cochabamba city (4,104/5,923, 69.3%; 2,558 m) and the highest incidence observed in Capinota (839 cases per 100,000 population; 2,386 m). Molecular analyses indicated predominant circulation of DENV-2 genotype II clade F.1.1.2. Phylogenetic reconstruction identified two distinct clades closely related to viruses previously detected in southern Brazil, suggesting multiple independent introductions into the department in late 2023. However, the limited availability of genomic data from Bolivia and neighboring countries limits precise identification of the outbreak's origin. This study provides the first characterization of the 2024 dengue outbreak in Cochabamba, an exceptional event of substantial DENV circulation at high altitude, likely facilitated by the expanding geographic range of Ae. aegypti, potentially driven by climate change.
Zika virus epidemiology in Bolivia: A seroprevalence study in volunteer blood donors
(Public Library of Science, 2018) Paola Mariela Saba Villarroel; Elif Nurtop; Boris Pastorino; Yelin Roca; Jan Felix Drexler; Pierre Gallian; Thomas Jaenisch; Isabelle Leparc-Goffart; Stéphane Priet; Läétitia Ninove
Analysis revealed that ZIKV circulation occurred in tropical areas (Beni: 39%; Santa Cruz de la Sierra: 21.5%) but not in highlands (~0% in Cochabamba, La Paz, Tarija). It was modulated by Aedes aegypti activity and the virus spread was not limited by previous immunity to dengue. Cases were geo-localised in a wide range of urban areas in Santa Cruz and Trinidad. No differences in seroprevalence related to gender or age-groups could be identified. It is concluded that ZIKV has been intensely circulating in the Beni region and has still a significant potential for propagating in the area of Santa Cruz.