Browsing by Autor "Paredes, Alejandro Javier"

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    Development and in vitro evaluation of solid dispersions as strategy to improve albendazole biopharmaceutical behavior.
    (2018) Simonazzi, Analía; Cid, Alicia Graciela; Paredes, Alejandro Javier; Schofs, Laureano; Gonzo, Elio Emilio; Palma, Santiago Daniel; Bermúdez, José María
    AIM: Solid dispersions using Poloxamer 407 as carrier were developed to improve albendazole (ABZ) solubility and dissolution profiles. METHODS: ABZ/poloxamer solid dispersions were prepared, and dissolution profiles were mathematically modeled and compared with physical mixtures, pharmaceutical ABZ and a commercial formulation. RESULTS: Poloxamer 407 increased exponentially ABZ solubility, in about 400% when 95% w/w of polymer compared with its absence. Solid dispersions initial dissolution rate was three to 20-fold higher than physical mixtures, the drug and the commercial formulation. All the solid dispersions required less than 2.2 min to reach an 80% of ABZ dissolution, while the commercial formulation needed around 40 min. CONCLUSION: Solid dispersions improved ABZ solubility and dissolution rate, which could result in a faster absorption and an increased bioavailability.