Browsing by Autor "Pierina Petrosino Tepedino"

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Adamantinoma: Una patología infrecuente en la edad pediátrica
(Universidad de Los Andes, 2018) Oriana Castanedo Rodríguez; Daniela Bravo Araujo; Pierina Petrosino Tepedino; Leyton Frances Stock
Adamantinoma is a rare, low grade, primary bone malignant tumor. Its rate of appearance on pediatric ages is minimal; therefore it could be misdiagnosed with several tumoral entities typical of childhood and puberty. We report the case of a 12-year-old teenager who coursed with increase of volume in the calf accompanied by intermittent pain, which was managed as osteosarcoma. After immunostaining tests were performed, the diagnostic of adamantinoma was established, leading to its surgical resolution and positive clinical outcome.
Características fenotípicas de células T linfocitarias de tipo regulador (Treg) presentes en el hígado de pacientes con infección crónica por VHB
(Universidad Internacional de La Rioja, 2012) Danely Velázquez; Melise Milano; Pierina Petrosino Tepedino; Asmiria Sotolongo; Luisa Barboza; Siham Salmen; Lisbeth Berrueta Carrillo
Hepatitis B virus (HBV) is responsible for irreversible liver damage. In this study we evaluated regulatory T cell that infiltrate the liver in hepatic biopsies from subjects with chronic HBV infection. Data showed a significant increase (p <0.05) in the number of CD4 + T cells co-expressing FoxP3, IL-10 or TGFâ, in HBV chronically infected patients, as compared with the other group of patients. This increase was positively correlated with plasma ALT levels (R= 0.9, p <0.05). There were not significant differences between the clinical groups, when liver infiltrating CD8 + populations were evaluated. These findings may contribute to understand events leading to failure of the immune response associated with recruitment of suppressor-type populations, which could inhibit specific immune response against HBV, therefore contributing to viral persistence.
Carcinoma urotelial primario de la trompa uterina, una patología infrecuente: reporte de un caso
(Universidad Internacional de La Rioja, 2013) Stefano Pozzobon-Borregales; Jesús Rico Castillo; Pierina Petrosino Tepedino; Melisse Milano Molina; Julio Cesar Lacruz
Primary Carcinoma of the uterine tube is an unusual malignant pathology that occurs between the 0,1% and the 1,8% of all malignant tumors, being the urothelial histological type even less frequent, which represents 10% of malignant tumors of the uterine tubes. These tumors usually appear in women between the 5th and 7th decades, and in 18% of the cases they become clinically manifest with the following triad: palpable mass and/ or abdominal distention, pain, and metrorrhagia. We present a case of a 44 year old woman who began current pathology in December 2010 with pelvic pain and continuous genital bleeding. The magnetic resonance reported a lesion that occupied the right parauterine space, and suggested a malignant neoplasia of the right ovary. The report of Ca-125 tumor marker showed high values, along with symptoms and paraclinic results that suggested a malignant disease. A gynecologic laparotomy was performed, with evidence of a right Fallopian tube tumor. The histological study was concluded as a Carcinoma with Urothelial differentiation. Afterwards, a staging surgery was performed, which included peritonea washing out, total hysterectomy, left salpingo-oophorectomy, omentectomy, appendicectomy, and selective, bilateral lymphadenectomy. The biopsy report from the surgical pieces was negative for malignancy. Actually, the patient is disease-free. This case was reported given the unusual of the pathology.
Lepra lepromatosa . A propósito de un caso clínico
(Universidad Internacional de La Rioja, 2014) Anays Toro; Silvana Vielma; Pierina Petrosino Tepedino; Melisse Milano Molina
A case reportAbstract Leprosy is a chronic infectious disease, declared by the WHO as successfully controlled since several years ago, is causal by an acid-alcohol-resistant bacilli (AARB) called Mycobacterium leprae. Infection has a long incubation period and mainly affects skin, mucous membranes and peripheral nerves. Its clinical presentation comprises two polar types, lepromatous leprosy (LL), tuberculoid leprosy (TL) and three borderline expressions. Here we report a case of a 36 year-old male patient, who suffers since two years ago skin lesions characterized by hyperchromic macules that progressed to nodules, initially in hands and feet, then spread throughout the body, without respect of palm of hands and feet. Preceded by Dengue infection (20 days before), and a histopathological diagnosis as Glomangiosarcoma. Upon admission, the patient had countless indurated, multiform and confluent nodular lesions, associated to unaltered superficial or deep sensitivity or neuromuscular symptoms. Radiological studies from thorax, abdomen and pelvis showed no musculoskeletal or visceral lesions without nodal involvement. The second biopsy reported chronic inflammation, few lymphocytic infiltrate, foamy macrophages, countless and slightly curved intracellular (macrophages) AARB. Lepromin test was negative reported. The final diagnosis was lepromatous leprosy. Triple multitherapy (dapsone, rifampicin, clofazimine) was prescribed and two months later, evidence of improvement in the number and size of lesions was observed. Early diagnoses through clinical, histopathological, immunological tests are central to the broader context of clinical presentations in Leprosy.
Paciente pediátrico con Lesión 0steolítica expansiva (Osteosarcoma Telangiectásico)
(2010) Carmen Fuenmayor; Maryori García; Pierina Petrosino Tepedino; Acacio Sandia; María del Pino Mathías Gutierrez
El osteosarcoma es el tumor maligno de hueso más frecuente en la infancia. Una de sus variantes el\nosteosarcoma telangiectásico puede confundirse ocasionalmente con quiste óseo aneurismático. El objetivo de\neste trabajo es comparar las características clínico morfológicas de estas dos entidades clínicas para evitar\nerrores diagnósticos en futuros casos. Para ello se presenta el caso de una niña de 6 años de edad, quien\nconsultó por aumento progresivo de volumen, dolor y limitación funcional en tercio proximal de pierna\nizquierda. La radiografía simple de tibia y peroné izquierdo al ingreso, mostró lesión osteolítica, metafisaria,\nradiolúcida y con bordes mal definidos. Histológicamente se observaron espacios quísticos con sangre,\nseparados por septos fibrosos muy finos. Ambos estudios se interpretaron como quiste óseo aneurismático. La\npaciente evolucionó tórpidamente, siendo necesaria la amputación supracondílea del miembro. La valoración\nretrospectiva de las biopsias concluye que el caso correspondía a un: osteosarcoma telangiectásico. Se resalta la\nimportancia de una adecuada correlación de las tumoraciones músculo-esqueléticas, que abarquen aspectos\nepidemiológicos, clínicos, radiológicos e histológicos. La evolución de la paciente posterior a quimioterapia fue\nsatisfactoria y en la actualidad esta libre de neoplasia.
Quiste epidermoide intradiploico parietal izquierdo. A propósito de un caso y revisión de la literatura
(Universidad de Los Andes, 2018) Daniel Alberto Zambrano Lizcano; Elbert Oberto Reyes Graterol; Juan Pablo Chacín González; Frances Stock; Pierina Petrosino Tepedino; Daniel Andrés Ramos Rubio
Epidermoid cysts are congenital benign, slow growing tumors, that account for 1% of all intracraneal tumors. In 25% of the cases they have an intradiploic localization an are exceptionally infratentorial. We present a 7-year-old escolar patient who presented a growing bulging of the scalp, associated with insidious, holocraneal, low intensity headache. The patient had personal history of migraine and epilepsy with complex partial seizures. Imaging studies reported a well-defined ovoid mass in the left parietal bone with lytic characteristics and 8,8x17mm of diameter. The surgical procedure was successful and the removal of the whole tumor was accomplished. Histopathological studies reported an epidermoid cyst.
Tumor sólido pseudopapilar de páncreas. Presentación de un caso reportado en Hospital Universitario de Los Andes, Mérida-Venezuela
(Universidad de Los Andes, 2013) Naisbet Ortega Vásquez; Melisse Milano Molina; Ana Valentina Rojas-Esquerre; Estrella Celeste Uzcátegui Paz; Carlos González Torres; Pierina Petrosino Tepedino; Asmiria Sotolongo; Elymar Barreto; Julio Tabares
El tumor solido pseudopapilar de pancreas es una neoplasia de bajo grado de malignidad, de etiologia incierta y relativamente raro con una incidencia de 0.2 a 2.7% entre los tumores de pancreas exocrino. Se presenta con mayor frecuencia en mujeres jovenes, siendo muy raro en varones, y existen pocos casos de mortalidad asociados a este tumor. Pueden encontrarse incidentalmente o dar sintomas abdominales inespecificos. Presentamos el caso de paciente femenina de 16 anos de edad, quien consulto por saciedad temprana y dolor abdominal tipo colico en epigastrio e hipocondrio derecho. Se realizo endoscopia digestiva superior puncion con aguja guiada (PAF) guiada por ultrasonido endoscopico de lesion quistica en cola de pancreas, con hallazgos compatibles con tumor solido pseudopapilar de pancreas. Se realizo Pancreatectomia corporo-caudal con estudio de biopsia, los cuales confirmaron el diagnostico preoperatorio. El tumor solido pseudopapilar pancreatico incluye entre sus manifestaciones clinicas dolor abdominal, sensacion de plenitud o saciedad temprana, masa abdominal, nauseas y vomitos, entre otras. La tomografia axial computarizada puede revelar masa heterogenea grande y encapsulada. El diagnostico definitivo se realiza con el estudio histopatologico y el tratamiento de eleccion es la cirugia, la cual por si sola tiene un nivel elevado de curacion. Solid-pseudopapillary tumor of the pancreas. A report in the Hospital Universitario de Los Andes, Merida-Venezuela Abstract Solid pseudopapillary tumor of the pancreas is a neoplasm of low malignant, of uncertain etiology and relatively rare with an incidence of 0.2 to 2.7% between exocrine pancreatic tumors. It occurs most often in young women and is very rare in men, and there are few cases of mortality associated with this tumor. May be found incidentally or give nonspecific abdominal symptoms. We report the case of a female patient aged 16, who consulted with early satiety and cramping abdominal pain in epigastrium and right hypochondrium. Upper gastrointestinal endoscopy was performed and a endoscopic ultrasound guided fine needle aspiration of the cystic lesiom was performed, with findings consistent with pancreatic solid pseudopapillary tumor. Pancreatectomy was performed porated-flow with biopsy study, which confirmed the preoperative diagnosis. Solid pseudopapillary tumor pancreatic includes among its clinical manifestations abdominal pain, fullness or early satiety, abdominal mass, nausea and vomiting, among others. Computed tomography may reveal large encapsulated heterogeneous mass. The definitive diagnosis is made by histological study and treatment of choice is surgery, which alone has a high level of healing.