Browsing by Autor "Ramirez-Rodriguez, Nelson"

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    Autoimmune hepatitis in pediatrics, a review by the Working Group of the Latin American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
    (2022) Ramonet, Margarita; Ramirez-Rodriguez, Nelson; Álvarez Chávez, Felipe; Arregui, María C; Boldrini, Gustavo; Botero Osorio, Verónica; Cuarterolo, Miriam; Godoy, Marcela; Medina Monroy, Fernando Alonso; Oropeza, Gabriela; Pérez Carusi, Rosana; Pérez Rodríguez, Diana; Reynoso-Zarzosa, Fátima Azereth; Ciocca, Mirta
    Autoimmune hepatitis (AIH) is a chronic inflammatory condition of the liver characterized by a complex interaction among genetic factors, immune response to antigens present in hepatocytes, and immune regulation alterations. Its distribution is global and there is a female predominance. AIH is divided into 2 groups, depending on the type of serum autoantibodies detected. The most common presentation is acute hepatitis (40%), with non-specific symptoms, high aminotransferase levels, and hypergammaglobulinemia. Standard treatment consists of the administration of immunosuppressive drugs. It is a complex condition, often difficult to diagnose. If not managed adequately, the 5-year mortality rate may reach 75%.