Browsing by Autor "Raquel Cruz"

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Author response: Novel risk loci for COVID-19 hospitalization among admixed American populations
(2024) Silvia Diz‐de Almeida; Raquel Cruz; André Ducati Luchessi; José M. Lorenzo-Salazar; Miguel López de Heredia; Inés Quintela; Rafaela González‐Montelongo; Vivian Nogueira Silbiger; Marta Sevilla Porras; Jair Tenorio
The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a GWAS for COVID-19 hospitalization in admixed Americans, comprising a total of 4,702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research.
Author response: Novel risk loci for COVID-19 hospitalization among admixed American populations
(2024) Silvia Diz‐de Almeida; Raquel Cruz; André Ducati Luchessi; José M. Lorenzo-Salazar; Miguel López de Heredia; Inés Quintela; Rafaela González‐Montelongo; Vivian Nogueira Silbiger; Marta Sevilla Porras; Jair Tenorio
Novel risk loci for COVID-19 hospitalization among admixed American populations
(2024) Silvia Diz‐de Almeida; Raquel Cruz; André Ducati Luchessi; José M. Lorenzo-Salazar; Miguel López de Heredia; Inés Quintela; Rafaela González‐Montelongo; Vivian Nogueira Silbiger; Marta Sevilla Porras; Jair Tenorio
Abstract The genetic basis of severe COVID-19 has been thoroughly studied and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we have conducted the largest GWAS meta-analysis for COVID-19 hospitalization in admixed Americans, comprising a total of 4,702 hospitalized cases recruited by SCOURGE and other seven participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and first discovered in Latin-American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort.
Novel risk loci for COVID-19 hospitalization among admixed American populations
(eLife Sciences Publications Ltd, 2024) Silvia Diz‐de Almeida; Raquel Cruz; André Ducati Luchessi; José M. Lorenzo-Salazar; Miguel López de Heredia; Inés Quintela; Rafaela González‐Montelongo; Vivian Nogueira Silbiger; Marta Sevilla Porras; Jair Tenorio
The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations ( BAZ2B and DDIAS ). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP . Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research.
Novel risk loci for COVID-19 hospitalization among admixed American populations
(eLife Sciences Publications Ltd, 2024) Silvia Diz‐de Almeida; Raquel Cruz; André Ducati Luchessi; José M. Lorenzo-Salazar; Miguel López de Heredia; Inés Quintela; Rafaela González‐Montelongo; Vivian Nogueira Silbiger; Marta Sevilla Porras; Jair Tenorio
The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research.
Novel risk loci for COVID-19 hospitalization among admixed American populations
(2024) Silvia Diz‐de Almeida; Raquel Cruz; André Ducati Luchessi; José M. Lorenzo-Salazar; Miguel López de Heredia; Inés Quintela; Rafaela González‐Montelongo; Vivian Nogueira Silbiger; Marta Sevilla Porras; Jair Tenorio
Abstract The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a GWAS for COVID-19 hospitalization in admixed Americans, comprising a total of 4,702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research.