Browsing by Autor "Ricardo Santiago Ramirez"

Now showing 1 - 3 of 3

S0504 Impact of Chronic Constipation on Economic Status and Work Productivity: A Prospective Case-Control Study
(Lippincott Williams & Wilkins, 2020) Francisco Alejandro Felix Tellez; Antonio Álvarez Martínez; Denisse Alejandra Picazo Mendoza; Melissa Encarnación Martínez; Ana Maria Coeto Cano; Francisco Daniel Lugo Vences; Daniel Eduardo Sandoval Colin; Angel Ricardo Flores Rendon; Ricardo Santiago Ramirez
INTRODUCTION: Chronic constipation (CC) prevalence is of 15% representing the sixth most common gastrointestinal symptom. Primary constipation can be due functional constipation (FC), constipation predominant irritable bowel syndrome (IBS-C) and defecatory disorders, this last one requiring abnormal anorectal tests. FC prevalence is of 20% affecting predominantly elderly; IBS-C affects younger population with a heterogenic prevalence varying from geographic regions (1.1-45%). Mounting evidence describes an impact of CC on quality of life (QOL) but there is limited data of economic status and work productivity (WP) influence by CC variants. METHODS: This study performed a prospective case-control design to analyze socioeconomic and WP impact of SII-C and FC on productive Mexican population. It took place on Mexico during 2020. Overall, 1000 active workers selected by random sampling completed an internet survey. This study collected social, demographic and WP information; and analyzed psychological and digestive symptoms. Rome IV criteria for SII-C and FC diagnosis, EQ-5D for QOL and Goldberg Scale for depression and anxiety. Comparisons with a regression univariate and multivariate analysis with chi-squared with 95% confidence intervals and a comparative T-test was used to analyze data. RESULTS: CC prevalence was 33.6% with a predominance of SII-C (61%) and in a less proportion FC (39%). No differences on the mean age being of 29 ± 10 years in SII-C and SII. Both groups affects predominantly female gender, in SII-C representing the 81.5% and 69.5% in FC. Per capita annual health spending was grater in SII-C at compared with FC (MXN 1,485 vs. MXN 905). Negative impact on WP was more frequent in SII-C with higher rates of ausenteeism and presenteeism at compared with FC. Multiple logistic regression indicated that presenteeism OR 1.769 (CI 95% 1.110–2.819, P = 0.017) and annual medical attention OR 4.248 (CI 95% 2.555–7.063, P < 0.001) were independently associated with SII-C without statistical association of FC with QOL, economics or work related variables. T-test indicated that there are no differences in per capital annual health spending, but a SII-C frequently sought medical attention at compared with FC (P = 0.002). CONCLUSION: In Hispanics, CC has the same prevalence reported worldwide, affecting younger population on work productive age. SII-C affects negatively WP being an independent factor for presenteeism. FC do not impact con WP. SII-C seek for medical attention with more frequency than FC.Table 1.: Multivariate analysis of associated factors to C-IBSTable 2.: T-Student analysis of associated factors to C-IBS
S1349 Impact of Chronic Nausea and Vomiting Syndrome on Work Productivity and Quality of Life: A Prospective Case-Control Study
(Lippincott Williams & Wilkins, 2020) Francisco Alejandro Felix Tellez; Antonio Álvarez Martínez; Denisse Alejandra Picazo Mendoza; Melissa Encarnación Martínez; Ana Maria Coeto Cano; Francisco Daniel Lugo Vences; Daniel Eduardo Sandoval Colin; Ricardo Santiago Ramirez; Angel Ricardo Flores Rendon
INTRODUCTION: Chronic nausea and vomiting syndrome (CNVS) is an uncommon functional nausea and vomiting disorder. It has been associated with several disorders of the brain-gut axis including irritable bowel syndrome and functional dyspepsia. The prevalence of functional nausea and vomiting disorders is 2.2% from which 50% are CNVS, affecting predominantly productive population. Mounting evidence has previously described a negative impact of CNVS on quality of life; however, the influence on work productivity it is reported in nausea and vomiting as isolated symptoms and not as part of CNVS. METHODS: A prospective case-control study was conducted to analyze socioeconomic and work productivity impact of CNVS on productive Mexican population. The research took place on Mexico during 2020. An internet survey was applied to 1000 active workers selected by random sampling. This study collected social, demographic and work related information; and analyzed psychological and digestive symptoms. Rome IV criteria for CNVS diagnosis, EQ-5D for evaluate quality of life (QOL) and Goldberg Scale for depression and anxiety. Comparisons with a logistic regression univariate and multivariate analysis with chi-squared test with 95% confidence intervals were calculated, as well as a comparative T-test. RESULTS: CNVS prevalence was 12.6%. Demographics were age of 30 ± 11 years with a predominance of female gender (66.3%). On CNVS, the mean age was (28 ± 9) with a predominance female gender (82.5%). Among employed with CNVS, 74% reported an impact on daily life versus 49% of those on the control group. Based on EQ-5D, pain-discomfort status was present on 48.4% and anxiety-depression status on 65%, 74.4% reported CNVS as a cause of presenteeism and 44.4% as a cause of annual absenteeism. Multiple logistic regression indicated that anxiety-depression overlap OR 2.104 (CI 95% 1.367-3.240, P = 0.001) and presenteeism OR 4.874 (CI 95% 2.784-8.536, P=< 0.001) were independently associated with CNVS, as well as male gender is a protective factor for developing CNVS OR 0.417 (CI 95% 0.248-0.699, P = 0.001). T-test indicated that CNVS patients have more per capital annual health spending and frequently sought medical attention (P=< 0.001). CONCLUSION: CNVS is more frequent on Hispanic population, affecting predominantly working age population. CNVS influences negatively in per capita annual health spending and work productivity being a common cause of absenteeism and presenteeism, as well as an independent factor for this last one.Table 1.: Multivariate analysis of associated factors to chronic nausea and vomiting syndromeTable 2.: T-Studen analysis of associated factors to chronic nausea and vomiting syndrome
Skeletal muscle: from birth to old age, routes to mechanical and metabolic failure.
(National Institutes of Health, 2019) Sofía Gitler; I Méndez Ramírez; Ricardo Santiago Ramirez; Joel Medina; Pável Vázquez; Alicia Ortega
Skeletal muscle (SM) is the most abundant tissue and the largest reservoir of protein in the body. It transports glucose in an insulin dependent manner by the glucose transporter type 4 (GLUT4) and contributes in the maintenance of serum amino acids concentration. By its mass and energetic requirements, it is fundamental for the systemic metabolic balance. In the present work, we present the effect of gestational undernourishment (GU) on the mechanical and metabolic properties of SM at birth and in old age in an animal model. Mechanical studies were performed on isolated muscles, while the GLUT4, amino acid transporters LAT2, SNAT2 and insulin receptors (IR) determination were performed on isolated transverse-tubule membranes (TT). The GU in offspring at birth, results in low muscle mass with increased contraction force and resistance to fatigue. However, in two-years old rats, there was muscle hypotrophy and sarcopenia, the force decreased between 50 and 70% in control rats and rats with GU respectively, accompanied by a lower expression of LAT2, SNAT2 and IR in TT. In conclusion, GU irreversibly affects the SM, an effect that could be similar in humans, which help us to understand the events that associate the GU with the metabolic debacle of SM and the metabolic diseases of human adulthood.