Browsing by Autor "Rodney Colina"

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    Evolution of naturally occurring 5'non-coding region variants of Hepatitis C virus in human populations of the South American region
    (BioMed Central, 2007) Gonzalo Moratorio; Mariela Martínez; María Fernanda Gutiérrez; Katiuska González; Rodney Colina; Luis Fernando López Tort; Lilia López; Ricardo Recarey; Alejandro G. Schijman; Pilar Moreno
    Phylogentic analysis revealed the presence of a sequence signature in the 5'NCR of type 1 HCV strains isolated in South America. This signature is frequent enough in type 1 HCV populations circulating South America to be detected in a phylogenetic tree analysis as a distinct type 1 sub-population. The coexistence of distinct type 1 HCV subpopulations is consistent with quasispecies dynamics, and suggests that multiple coexisting subpopulations may allow the virus to adapt to its human host populations.