Browsing by Autor "Rodolfo R. Rosales"

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Attention Deficit Hyperactivity Disorder: Advances in Epidemiology, Pathogenesis, and Neurobiology
(2025) Freddy Ednildon Bautista-Vanegas; Rodolfo R. Rosales; Ingrid Neysa Cabezas-Soliz; Daniel Ramiro Elías Vallejos-Rejas; Carmen Julia Salvatierra Rocha; Jhossmar Cristians Auza-Santiváñez; L. Castedo; Delly Espejo-Alanoca; Isaura Oberson Santander
Introduction. ADHD is a neurodevelopmental condition that affects approximately 5-7% of children and adolescents and persists in a significant number of cases into adulthood, with an estimated prevalence of 2.5% in adults globally. The impact goes far beyond school or work performance; it is associated with an increased risk of accidents, risky behaviors, comorbid disorders such as anxiety, depression, substance use disorders, and a significant reduction in quality of life. Methods. A search was conducted in the databases SciELO, Scopus, PubMed/MedLine, Google Scholar, Cochrane Library, as well as Clinical Keys services. The search terms for the search formulation were "ADHD", "Attention Deficit Disorder", "Hyperactivity", "depression", "autism spectrum", "anxiety", as well as their translations into English. Results. The reported prevalence of ADHD in children ranges from 2 to 18 percent depending on the diagnostic criteria and the population studied. The prevalence in school-aged children is estimated to be between 9 and 15 percent, making it one of the most common childhood disorders. Possible etiological factors include comorbid disorders, oppositional defiant disorder, conduct disorder, anxiety disorder, depression, developmental coordination disorder, autism spectrum disorder, and sleep disorders. Conclusion: ADHD constitutes a complex neurodevelopmental condition whose impact transcends clinical boundaries to become a multifaceted challenge for public health, neuroscience, and social justice.
Bioprocess Engineering: Advances in Cell Culture Systems, Reactor Design, Scale-up Strategies, and Intensification Processes for the Production of Biological and Bioactive Compounds
(2025) Freddy Ednildon Bautista-Vanegas; Jose Luis Diaz-Guerrero; Ingrid Neysa Cabezas-Soliz; Blas Apaza-Huanca; E Fernández; Jhossmar Cristians Auza-Santiváñez; Themis Karim Ocampo Gamboa; Rodolfo R. Rosales; Luis Mariano Tecuatl Gómez; Pablo Carías
Bioprocess engineering is undergoing an unprecedented transformation, driven by the growing demand for complex and bioactive biological products across diverse industries, from pharmaceuticals to food and energy. Recent advances have redefined the efficiency, scalability, and sustainability of biomanufacturing. Key elements of this evolution include the widespread adoption of single-use systems, the integration of automation and artificial intelligence (AI) for precise control and predictive optimization, and the fundamental shift toward continuous bioprocessing. These innovations not only reduce costs and production times but also improve product quality and consistency, enabling the manufacturing of personalized therapies and high-value compounds. Scaling strategies have diversified to include both scale-up and parallel expansion (scale-out), tailored to specific product needs. Together, these developments are laying the foundation for more agile, cost-effective, and environmentally responsible biomanufacturing, preparing the industry to address global challenges in health and sustainability.
Knowledge, attitudes and behaviors regarding nutrition among students of the School of Public Health - Tekove Katu in Bolivia
(2025) Paola Kattya Barrientos Lujan; Blas Apaza-Huanca; Iris Ingrid Carrillo-Campos; Benito Aguirre-Cruz; Delly Espejo-Alanoca; Rodolfo R. Rosales; Lisbet Carolay Cordova Mamani; Jhossmar Cristians Auza-Santiváñez
Introduction: Food is an essential component in the socio-cultural and economic context of communities. In Bolivia, malnutrition and food security problems are prevalent, especially in indigenous communities. The "Tekove Katu" Health School is an ideal setting for the implementation of nutritional education programs, given its intercultural approach and the potential impact on the food practices of students and their communities.Methods: Study design: Descriptive, cross-sectional observational study in students from indigenous communities during the month of February - December 2023. Universe and sample: 100% of students enrolled in 2023 were included. Exclusion criteria: Not wanting to participate in the research Not attending during the days in which the questionnaire was applied. Procedure: The data were collected through a self-administered questionnaire.Results and discussion: The results indicated that 82.55% of the participants expressed an appropriate conceptualization of healthy eating; However, a significant dissonance was evident between theoretical understanding and eating behaviors. Consumption patterns characterized by a dichotomy between the recognition of nutritional principles (91.86% expressed interest in healthy eating) and suboptimal eating practices (95.38% consumption of sweets, 83.07% consumption of hamburgers).Conclusions: At the "TEKOVE KATU" Health School, there is a predominance of the female gender and a higher concentration of students in the age range of 17 to 19 years. The parents of the students have a low educational level, and most of the students live with more than four people. A positive attitude towards the interest in eating healthily is highlighted, although a preference for foods rich in fats, refined sugars and sodium is also observed, despite recognizing that these are unhealthy. A large majority of students receive limited and unreliable information on food and nutrition, which highlights the need for a more solid nutritional education. It is clear that, in the absence of nutritional education and healthy eating programs, students do not have a solid foundation to consolidate healthy eating habits, which constitutes a public health problem with implications for morbidity and mortality, quality of life, health expenditure and an increase in chronic non-communicable diseases