Browsing by Autor "Rodrigo Vargas"

Now showing 1 - 4 of 4

Electrochemical technologies as modular adaptative decentralized treatment systems to enact water security for Latin America: Insights and prospects
(Elsevier BV, 2023) Alexsandro J. dos Santos; Rodrigo Vargas; Carla Oporto; Marcos R.V. Lanza; Abdoulaye Thiam; Ricardo A. Torres-Palma; Ricardo González-Rodríguez; Ulises Jäuregui‐Haza; Velia Sosa; Patricio J. Espinoza‐Montero
Elevation of Pulmonary Artery Pressure in Newborns from High-Altitude Pregnancies Complicated by Preeclampsia
(Multidisciplinary Digital Publishing Institute, 2023) Carlos E. Salinas-Salmon; Carla Murillo-Jauregui; Marcelino Gonzales; Vannia Espinoza-Pinto; Silvia V. Mendoza; Rosario Ortega Ruiz; Rodrigo Vargas; Yuri Pérez; Jaime Montaño; Lilian Toledo
We hypothesized that fetal exposure to the oxidative stress induced by the combined challenge of preeclampsia (PE) and high altitude would induce a significant impairment in the development of pulmonary circulation. We conducted a prospective study in La Paz (Bolivia, mean altitude 3625 m) in which newborns from singleton pregnancies with and without PE were compared (PE group n = 69, control n = 70). We conducted an echocardiographic study in these infants at the median age of two days. The percentage of cesarean deliveries and small for gestational age (SGA) infants was significantly higher in the PE group. Heart rate, respiratory rate, and oxygen saturation did not vary significantly between groups. Estimated pulmonary arterial pressure and pulmonary vascular resistance were 30% higher in newborns exposed to PE and high altitude compared with those exposed only to high altitude. We also detected signs of right ventricular hypertrophy in infants subjected to both exposures. In conclusion, this study provides evidence that the combination of PE and pregnancy at high altitude induces subclinical alterations in the pulmonary circulation of the newborn. Follow-up of this cohort may provide us with valuable information on the potential increased susceptibility to developing pulmonary hypertension or other pulmonary and cardiovascular disorders.
Preeclampsia and risk of maternal pulmonary hypertension at high altitude in Bolivia
(Cambridge University Press, 2023) Carlos E. Salinas; Olga Patey; Clara Murillo; Marcelino Gonzales; V. Espinoza; S. Mendoza; R. Ruı́z; Rodrigo Vargas; Yalile Perez; Juan José Montaño Moreno
Women with a history of preeclampsia (PE) have a greater risk of pulmonary arterial hypertension (PAH). In turn, pregnancy at high altitude is a risk factor for PE. However, whether women who develop PE during highland pregnancy are at risk of PAH before and after birth has not been investigated. We tested the hypothesis that during highland pregnancy, women who develop PE are at greater risk of PAH compared to women undergoing healthy highland pregnancies. The study was on 140 women in La Paz, Bolivia (3640m). Women undergoing healthy highland pregnancy were controls (C, n = 70; 29 ± 3.3 years old, mean±SD). Women diagnosed with PE were the experimental group (PE, n = 70, 31 ± 2 years old). Conventional (B- and M-mode, PW Doppler) and modern (pulsed wave tissue Doppler imaging) ultrasound were applied for cardiovascular íííassessment. Spirometry determined maternal lung function. Assessments occurred at 35 ± 4 weeks of pregnancy and 6 ± 0.3 weeks after birth. Relative to highland controls, highland PE women had enlarged right ventricular (RV) and right atrial chamber sizes, greater pulmonary artery dimensions and increased estimated RV contractility, pulmonary artery pressure and pulmonary vascular resistance. Highland PE women had lower values for peripheral oxygen saturation, forced expiratory flow and the bronchial permeability index. Differences remained 6 weeks after birth. Therefore, women who develop PE at high altitude are at greater risk of PAH before and long after birth. Hence, women with a history of PE at high altitude have an increased cardiovascular risk that transcends the systemic circulation to include the pulmonary vascular bed.
Preeclampsia and Risk of Maternal Pulmonary Hypertension at High Altitude in Bolivia
(RELX Group (Netherlands), 2022) Carlos E. Salinas; Olga Patey; Carla Victoria Jara Murillo; Marcelino Gonzales; Vania Espinoza; Silvia Mendoza; Rosario Ruiz; Rodrigo Vargas; Yuri Vázquez Pérez; Jaime Montaño