Browsing by Autor "Selma Alin Somilleda-Ventura"

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Association Between ACE Gene I/D Polymorphism and Diabetic Retinopathy in Mexican Population
(Elsevier BV, 2025) Karla Barrera-Perales; Héctor Javier Pérez-Cano; Sergio Rojas Juárez; Óscar Morales-López; Selma Alin Somilleda-Ventura; Miguel Ángel Cuevas‐Budhart; Ricardo Rueda
Correlación entre la densidad de perfusión y el grosor de la capa de células ganglionares en sujetos sin diabetes y en pacientes diabéticos sin retinopatía
(Elsevier BV, 2021) Guillermo Serrato-Martín; Dulce Milagros Razo Blanco-Hernández; Selma Alin Somilleda-Ventura; Virgilio Lima-Gómez
\n\tObjetivo: Comparar la correlación entre la densidad de perfusión y el grosor de la capa de células ganglionares en sujetos sin diabetes y diabéticos sin retinopatía. Método: Estudio observacional, retrospectivo, comparativo y transversal, en sujetos sin diabetes (grupo 1) y diabéticos sin retinopatía (grupo 2) evaluados mediante tomografía de coherencia óptica y angiotomografía de coherencia óptica (Cirrus con Angioplex). Se compararon entre grupos la densidad de perfusión por cuadrantes (mapa de 3 × 3 mm), el grosor de la capa de células ganglionares por sectores (U de Mann-Whitney) y la correlación entre variables por grupo (Rho de Spearman). Resultados: Se incluyeron 34 sujetos en el grupo 1 y 38 en el grupo 2. Las densidades de perfusión interna, completa, superior y nasal fueron menores en el grupo 2 (p < 0.05); el grosor de la capa de células ganglionares no difirió entre grupos en ningún sector. Hubo correlaciones débiles entre la densidad de perfusión interna y completa y los grosores de la capa de células ganglionares en el grupo 1; en el grupo 2 hubo correlaciones débiles entre la perfusión del cuadrante inferior y el grosor de los sectores inferior e inferior temporal, donde la densidad de perfusión no difirió de la del grupo 1. Conclusiones: La correlación entre la densidad de perfusión y el grosor de la capa de células ganglionares es débil en los sujetos sin diabetes y se pierde en los pacientes diabéticos sin retinopatía, porque en ellos solo la densidad de perfusión es menor.\n
Eficacia de un cuestionario sobre fotopsias para detectar lesiones de riesgo para desprendimiento de retina
(2020) Dulce Milagros Razo Blanco-Hernández; Selma Alin Somilleda-Ventura; Román Ramírez-Marín; María G. Colas-Calvere; Virgilio Lima-Gómez
Introduccin: Las fotopsias son fenmenos visuales que acompaan a condiciones patolgicas de la retina, como el desprendimiento de retina. Sin embargo en ocasiones su presencia pasa desapercibida
Nrf2 aqueous humor shows a higher concentration when GFAP is low in patients with diabetic cataracts versus those with senile cataracts
(2025) Selma Alin Somilleda-Ventura; Astrid Lucero Espinosa Soto; L Cerrillo; Otto Berger; Rosario Gulías-Cañizo
Oxidative stress is involved in aging and ocular diseases, so it is necessary to evaluate the serum and aqueous humor concentrations of Nrf2 and GFAP as possible indicators of neuro-oxidative damage in patients with senile or diabetic cataracts. Observational, prospective, cross-sectional, and comparative study; we obtain serum and aqueous humor samples from patients with senile cataracts (reference group) or diabetic cataracts. Concentrations of Nrf2 and GFAP were determined by the ELISA technique, compared with the Student´s t-test, and correlated with Spearman´s Rho test. Eighty patients included, 36 with senile and 44 with diabetic cataracts. The glucose concentration was 40.75 mg/dL higher in the diabetic group (p < 0.001), as well as the proportion of systemic arterial hypertension (p = 0.02). Concentrations of Nrf2 and GFAP were only quantifiable in the aqueous humor samples, showing opposed values between the groups (Nrf2 was significantly superior in patients with diabetic cataracts, and GFAP higher in patients with age-related cataracts, without statistical difference); positive correlations were higher in when diabetic cataracts exist (r = 0.59). Our findings suggest an accentuated response of the Nrf2 pathway by the significant increase of this molecule in patients with diabetes and cataracts possibly to compensate for the ROS overexpression, meanwhile in patients with senile cataracts, GFAP has higher (but non-statistical) concentrations, maybe due to a lower Nrf2 modulation.
Relationship between Helicobacter pylori and idiopathic non-granulomatous anterior uveitis
(Research Square (United States), 2022) Héctor Javier Pérez-Cano; Jimena Ceja-Martínez; Vanessa Tellezgiron-Lara; S. Voorduin-Ramos; Óscar Morales-López; Selma Alin Somilleda-Ventura
Abstract Purpose : The relationship of Helicobacter pylori infection with ocular diseases, including anterior uveitis, has been reported. The objective of this study was to determine the presence of anti-H. pylori IgG antibodies in patients with idiopathic non-granulomatous anterior uveitis and compare the results with a control group. Methods : A prospective, comparative and cross-sectional study was conducted. Patients with idiopathic granulomatous anterior uveitis and a group of control subjects were included. The presence of anti-H. pylori IgG antibodies was determined. Chi square test was performed for comparative analysis with GraphPad Prism V5.0 software Results : 30 patients with idiopathic non-granulomatous anterior uveitis and 35 control subjects were included. In the determination of anti-H. pylori IgG antibodies, 24 (80%) patients and 19 (54%) control subjects were positive. A significant difference (p = 0.0263) was found between the groups and a odds ratio (OR) of 3.37. Conclusions : A direct relationship was found between the presence of anti H. pylori IgG antibodies and idiopathic non-granulomatous anterior uveitis. An association can be established between idiopathic non-granulomatous anterior uveitis and H. pylori infection, without this being a causal or physiopathogenic relationship.
Relationship between Helicobacter pylori and undifferentiated non-granulomatous anterior uveitis
(Springer Science+Business Media, 2023) Héctor Javier Pérez-Cano; Jimena Ceja-Martínez; Vanessa Tellezgiron-Lara; S. Voorduin-Ramos; Óscar Morales-López; Selma Alin Somilleda-Ventura
SARS-CoV-2: ¡está presente en la conjuntiva?
(Elsevier BV, 2021) Selma Alin Somilleda-Ventura; Héctor Javier Pérez-Cano; Óscar Morales-López; Monserrat Y. Garrido-Santos
La familia Orthocoronavirinae fue descubierta en la década de 1960. Son virus envueltos de ARN monocatenario positivo y el tamaño de su genoma varía aproximadamente entre 26 y 32 kb, siendo el más grande para un virus ARN. En México, el primer caso reportado fue el de una persona proveniente de Italia. Tomando este como día 1, los casos se han ido incrementando y, hasta el momento de escribir el presente artículo, se tenían contabilizadas 133,974 personas infectadas y 15,944 decesos. La conjuntiva se ha propuesto como vía de entrada para el SARS-CoV-2. Sin embargo, en una búsqueda de material genético del coronavirus en muestras de lagrima y conjuntiva, los pacientes que no mostraban conjuntivitis resultaron negativos a la presencia de material genético viral, y solo una persona resultó positiva, tanto en muestras de lagrima como de conjuntiva. Los resultados negativos de ARN del SARS-CoV-2 en las lágrimas y las secreciones conjuntivales podría indicar que el virus no se replica en los epitelios conjuntivales, pero podría estar presente en cantidades no detectables, lo que no descarta que pueda ser transmitido a través de la conjuntiva.\n
TNFα and IL-8 vitreous concentrations variations with two antidiabetic therapies in patients with proliferative diabetic retinopathy: an observational study
(BioMed Central, 2024) Óscar Morales-López; Octavio Rodríguez‐Cortés; Pedro López‐Sánchez; Héctor Javier Pérez-Cano; Omar García-Liévanos; Virgilio Lima-Gómez; Selma Alin Somilleda-Ventura
Vision-related quality of life after surgery for vitreoretinal disorders: an observational study
(Research Square (United States), 2022) Ilse Sarahí Márquez-Vergara; Geovanni Jassiel Ríos-Nequis; Ingrid Yazmín Pita-Ortíz; Héctor Javier Pérez-Cano; Selma Alin Somilleda-Ventura
Abstract Background: Visual-related quality of life is not always included as a variable of surgical success. However, some questionnaires such as the Visual Function Quality-25 in the Spanish version have proven their reliability and validity, but the quality of life in patients undergoing surgery has not been explored in the Mexican population; so, this study aims to identify it in patients with the most prevalent vitreoretinal diseases.Methods: The Visual Function Quality-25 questionnaire was applied to 76 patients with advanced diabetic retinopathy, rhegmatogenous retinal detachment, and other causes of vitrectomy, pre-and postoperative. It was divided into 10-domains and interpreted according to the National Eye Institute scores, where the highest value was the best visual function. Student's t-test for related samples and Wilcoxon's t-test were used to compare each domain between measurements, and Pearson´s R test to correlate age and quality of life total score; a p-value <0.05 was considered significant.Results: Diabetic retinopathy patients showed an improvement after surgery in all domains, one and three months after surgery; the higher scores were in those who used air o gas as tamponade. In patients with rhegmatogenous retinal detachment, there was an improvement in almost all the items from the first month, with a higher difference observed up to three months, while a decrease in ocular pain was observed in other causes of vitrectomy. Differences found in all the quality-of-life scores at one versus three months were not statistical, but clinically significant.Conclusions: The study shows that visual-related quality of life domains improve after vitrectomy, predominately in diabetic retinopathy subjects; inclusion of this analysis might be considered relevant within the parameters of surgical success of the most prevalent vitreoretinal diseases.