Browsing by Autor "Suelene B. N. Tavares"
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Item type: Item , Deep Sequencing of the Trypanosoma cruzi GP63 Surface Proteases Reveals Diversity and Diversifying Selection among Chronic and Congenital Chagas Disease Patients(Public Library of Science, 2015) Martin Llewellyn; Louisa A. Messenger; Alejandro O. Luquetti; Lineth García; Faustino Torrico; Suelene B. N. Tavares; Bachar Cheaib; Nicolas Derôme; Marc Délepine; Céline BaulardOur results shed light on the diversity of parasite DTUs within each patient, as well as the extent to which parasite strains pass between mother and foetus in congenital cases. Although we were unable to find any evidence that parasite diversity accumulates with age in our study cohorts, putative diversifying selection within members of the TcGP63I gene family suggests a link between genetic diversity within this gene family and survival in the mammalian host.Item type: Item , The Trypanosoma cruzi Satellite DNA OligoC-TesT and Trypanosoma cruzi Kinetoplast DNA OligoC-TesT for Diagnosis of Chagas Disease: A Multi-cohort Comparative Evaluation Study(Public Library of Science, 2014) Koen De Winne; Philippe Büscher; Alejandro O. Luquetti; Suelene B. N. Tavares; Rodrigo Arruda de Oliveira; Aldo Solari; Inés Zulantay; Werner Apt; Patricio Diosque; Mercedes RumiSpecificities of the two T. cruzi OligoC-TesT prototypes are high on non-endemic and endemic controls. Sensitivities are moderate but significantly (p = 0.0004) higher for the kDNA OligoC-TesT compared to the satDNA OligoC-TesT.