Browsing by Autor "Valdivia, Ana C"

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    Activation of the free fatty acid receptor GPR40 by (+)-curcuphenol and related synthetic compounds
    (Rev. Bol. Quim, 2009) Valdivia, Ana C; Boketof, Åke; Olde, Björn; Owman, Christer; Vilaseca, Antonio; Fuentes, Lenny; Sterner, Olov
    The bio-guided fractionation of an ethanol extract of Baccharis genistelloides (L) Baker, a plant that traditionally is used to treat diabetes, yielded (+)-curcuphenol (1) as agonist of GPR40, a cell surface receptor for free fatty acids. This paper describes the agonistic activity of 1 as well as of a series of semi-synthetic and synthetic analogues
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    Prenylated protocatechuic acid derivatives with anti-oxidant activity from Piper heterophyllum
    (Rev. Bol. Quim, 2009) Valdivia, Ana C; Mollinedo, Patricia; Vilaseca, Antonio; Sterner, Olov
    Two new protocatechuic acid derivatives, arieianoic acid (1) and arieianol (2), were isolated from the aerial parts of Piper heterophyllum Ruíz & Pavon and their structures were determined by spectroscopic techniques. From 1, the semi-synthetic derivatives 3-8 were prepared. The antioxidant activity of the natural and semi-synthetic derivatives were evaluated using the DPPH assay