Browsing by Autor "Wilson García"

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    A strategy for scaling up access to comprehensive care in adults with Chagas disease in endemic countries: The Bolivian Chagas Platform
    (Public Library of Science, 2017) María‐Jesús Pinazo; Jimy Pinto; Lourdes Ortiz; Jareth Sánchez; Wilson García; Ruth Saravia; Mirko Rojas Cortez; Silvia Moriana; Enric Grau; Daniel Lozano
    This strategy provides a solution to unmet demands in the care of patients with CD, improving access to diagnosis and treatment. Further scaling up of diagnosis and treatment will be based on the expansion of the model of care to the NHS structures. Its sustainability will be ensured as it will build on existing local resources in Bolivia. Still human trained resources are scarce and the high staff turnover in Bolivia is a limitation of the model. Nevertheless, in a preliminary two-years-experience of scaling up this model, this limitations have been locally solved together with the health local authorities.
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    New chemotherapy regimens and biomarkers for Chagas disease: the rationale and design of the TESEO study, an open-label, randomised, prospective, phase-2 clinical trial in the Plurinational State of Bolivia
    (BMJ, 2021) Cristina Alonso‐Vega; Julio A. Urbina; Sergi Sanz; María‐Jesús Pinazo; Jimy Pinto; Virginia Gonzalez; Gimena Rojas; Lourdes Ortiz; Wilson García; Daniel Lozano
    NCT03981523.
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    New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial
    (Elsevier BV, 2021) Faustino Torrico; Joaquím Gascón; Fabiana Barreira; Bethania Blum; Igor C. Almeida; Cristina Alonso‐Vega; Tayná Barboza; Graeme Bilbe; Erika Correia; Wilson García
    For the Spanish translation of the abstract see Supplementary Materials section.
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    Rapid diagnostic tests duo as alternative to conventional serological assays for conclusive Chagas disease diagnosis
    (Public Library of Science, 2017) Karina E. Egüez; Julio Alonso-Padilla; Carolina Terán; Zenobia Chipana; Wilson García; Faustino Torrico; Joaquím Gascón; Daniel-Franz Lozano-Beltran; María‐Jesús Pinazo
    Chagas disease is caused by the parasite Trypanosoma cruzi. It affects several million people, mainly in Latin America, and severe cardiac and/or digestive complications occur in ~30% of the chronically infected patients. Disease acute stage is mostly asymptomatic and infection goes undiagnosed. In the chronic phase direct parasite detection is hampered due to its concealed presence and diagnosis is achieved by serological methods, like ELISA or indirect hemagglutination assays. Agreement in at least two tests must be obtained due to parasite wide antigenic variability. These techniques require equipped labs and trained personnel and are not available in distant regions. As a result, many infected people often remain undiagnosed until it is too late, as the two available chemotherapies show diminished efficacy in the advanced chronic stage. Easy-to-use rapid diagnostic tests have been developed to be implemented in remote areas as an alternative to conventional tests. They do not need electricity, nor cold chain, they can return results within an hour and some even work with whole blood as sample, like Chagas Stat-Pak (ChemBio Inc.) and Chagas Detect Plus (InBIOS Inc.). Nonetheless, in order to qualify a rapidly diagnosed positive patient for treatment, conventional serological confirmation is obligatory, which might risk its start. In this study two rapid tests based on distinct antigen sets were used in parallel as a way to obtain a fast and conclusive Chagas disease diagnosis using whole blood samples. Chagas Stat-Pak and Chagas Detect Plus were validated by comparison with three conventional tests yielding 100% sensitivity and 99.3% specificity over 342 patients seeking Chagas disease diagnosis in a reference centre in Sucre (Bolivia). Combined used of RDTs in distant regions could substitute laborious conventional serology, allowing immediate treatment and favouring better adhesion to it.
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    Safety of Alternative Benznidazole and Nifurtimox Regimens for Adults with Chronic Trypanosoma Cruzi Infection (TESEO): An Open-Label, Randomised, Non-Inferiority Phase 2 Trial
    (RELX Group (Netherlands), 2026) Cristina Alonso-Vega; Jimy José Pinto; Gimena Rojas; Wilson García; Alejandro Palacios; Susana Méndez; Virginia Gonzalez; Mónica Laserna; Isabela Ribeiro; E. Ruíz-Villamor