Browsing by Autor "Xiomara Ramirez"

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    Effectiveness and Limitations of the Use of the Gonadotropin-Releasing Hormone Agonist Leuprolide Acetate in the Diagnosis of Delayed Puberty in Males
    (Karger Publishers, 1997) Roberto Lanes; Peter Günczler; Jesús A. Osuna; Anselmo Palacios; Eduardo Carrillo; Xiomara Ramirez; Coromoto Garcia; Mariela Paoli; Omar Villaroel
    In order to evaluate the effectiveness of the gonadotropin-releasing hormone agonist leuprolide acetate in distinguishing gonadotropin deficiency from delayed puberty, a single subcutaneous dose of 20 micrograms/kg of leuprolide acetate was administered at 07.00 h to 14 patients with constitutionally delayed puberty and to 8 gonadotropin-deficient subjects, and serum gonadotropin and testosterone levels were determined at baseline and 1,2,3,6,12, and 24 h thereafter. The increase in gonadotropin and testosterone levels was significant in patients with delayed puberty, so that the mean peak luteinizing hormone and to a lesser degree the mean peak testosterone levels clearly differentiated normally delayed from gonadotropin-deficient puberty. However, when the peak gonadotropin and testosterone concentrations were analyzed individually, there was a considerable overlap between the two groups of males, limiting the usefulness of this test.