Browsing by Autor "Yelin Roca"

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21-Hydroxylase gene mutant allele CYP21A2∗15 strongly linked to the resistant HLA haplotype B∗14:02-DRB1∗01:02 in chronic Chagas disease
(Elsevier BV, 2013) Florencia del Puerto; Mihoko Kikuchi; Juan Eiki Nishizawa; Yelin Roca; Cinthia Avila; Alberto Gianella; Javier Lora; Freddy Udalrico Gutierrez Velarde; Kenji Hirayama
An epidemiological study of Taenia solium cysticercosis in a rural population in the Bolivian Chaco
(Elsevier BV, 2001) Juan Carrique‐Mas; Naomi Iihoshi; Marc‐Alain Widdowson; Yelin Roca; G Morales; J. L. Quiroga; F Cejas; M Caihuara; Rodríguez Ibarra; Martyn Edelsten
Caracteristicas de las epidemias de dengue en la ciudad de Santa Cruz (2003-2007)
(2009) Yelin Roca; C Avila; Eva Fabbiana Bez Galarza; J. Pachuri; Jorge Vargas; Annie Walter; Jean-Pierre Hervé
International audience
Clinical significance of intra-host variability of Dengue-1 virus in venous and capillary blood
(Elsevier BV, 2013) Élodie Descloux; C. La Fuentez; Yelin Roca; Xavier de Lamballerie
Combination of ELISA screening and seroneutralisation tests to expedite Zika virus seroprevalence studies
(BioMed Central, 2018) Elif Nurtop; Paola Mariela Saba Villarroel; Boris Pastorino; Läétitia Ninove; Jan Felix Drexler; Yelin Roca; Bouba Gaké; Audrey Dubot‐Pérès; Gilda Grard; Christophe N. Peyrefitte
Correction to: Combination of ELISA screening and seroneutralisation tests to expedite Zika virus seroprevalence studies
(BioMed Central, 2019) Elif Nurtop; Paola Mariela Saba Villarroel; Boris Pastorino; Läétitia Ninove; Jan Felix Drexler; Yelin Roca; Bouba Gaké; Audrey Dubot‐Pérès; Gilda Grard; Christophe N. Peyrefitte
Effectiveness of monovalent rotavirus vaccine in Bolivia: case-control study
(2013) Manish M. Patel; Maritza Patzi; Darwin Pastor; AL Nina; Yelin Roca; Luisa Álvarez; Volga Iñiguez; Rosario Rivera; Ka Ian Tam; Osbourne Quaye
The monovalent rotavirus vaccine conferred high protection against hospital admission for diarrhea due to rotavirus in Bolivian children. Protection was sustained through two years of life against diverse serotypes different from the vaccine strain.
El dengue en Bolivia: la epidemia de 2006-2007 y análasis retrospectivo de los datos virológos
(Centre National de la Recherche Scientifique, 2007) Yelin Roca; Jimmy Revollo; C. Avila; A.-M. Rocabado; J. Pachuri; Gilbert Le Goff; Jean-Pierre Hervé
International audience
Epidemiological analysis of the influenza A(H1N1)v outbreak in Bolivia, May-August 2009
(European Centre for Disease Prevention and Control, 2009) Alberto Gianella; Azibadighi Walter; Roberto Jimmy Revollo; Roxana Loayza; Jorge Vargas; Yelin Roca
The outbreak of pandemic influenza (H1N1) began in Bolivia on 25 May 2009. Between May and August, the National Center of Tropical Disease (CENETROP) analysed by RT-PCR 7,060 samples of which 12.7% were positive. A preliminary analysis of the 895 confirmed cases identified between May and August 2009 describes epidemiological and clinical characteristics. After the first imported cases from the United States and Peru, the locally acquired infections predominated (90%). The number of cases was highest in the age group of 10 to 29 year-olds, and 89.6% of cases were observed in people under the age of 40 years. Fever, cough, nasal discharge and headache remained the main symptoms.
Evaluation of the Human IgG Antibody Response to Aedes albopictus Saliva as a New Specific Biomarker of Exposure to Vector Bites
(Public Library of Science, 2012) Souleymane Doucouré; François Mouchet; Sylvie Cornélie; J.S. Dehecq; Abdul Hamid Rutee; Yelin Roca; Annie Walter; Jean Pierre Hervé; Dorothée Missé; F. Favier
Ab responses to saliva could be used as an immuno-epidemiological tool for evaluating exposure to Aedes albopictus bites. Combined with entomological and epidemiological methods, a "salivary" biomarker of exposure to Aedes albopictus could enhance surveillance of its spread and the risk of arbovirus transmission, and could be used as a direct tool for the evaluation of Aedes albopictus control strategies.
Evolution of Dengue Disease and Entomological Monitoring in Santa Cruz, Bolivia 2002 – 2008
(Public Library of Science, 2015) Philippe Brémond; Yelin Roca; Simone Frédérique Brénière; Annie Walter; Zaira Barja-Simon; Roberto Torres Fernández; Jorge Vargas
Over the years, the increasing trend of dengue cases has been highlighted as well as its widespread distribution over the entire city, but an underestimation of the number of cases is strongly suspected. Contrary to popular belief, the city center appears more affected than the periphery, and dengue is not particularly related to waste. Interestingly, the clinical diagnosis of dengue by physicians improved over the years, whatever the gender, age and residential area of suspected cases.
Genome Sequences of Chikungunya Virus Isolates from Bolivia
(American Society for Microbiology, 2020) Caio M B França; Roxana Loayza; Yelin Roca; Ana Maria Montaño Arias; Freddy Tinajeros; José R. Loaiza; Anshule Takyar; Robert H. Gilman; Matthew J. Miller
We generated nine coding-complete chikungunya virus genome sequences from blood samples collected during the early 2015 outbreak in Bolivia. Relative to other publicly available chikungunya sequences, the Bolivian samples represent a monophyletic group, suggesting that a single lineage was widely circulating in the country between February and May 2015.
Human Antibody Response to Aedes aegypti Saliva in an Urban Population in Bolivia: A New Biomarker of Exposure to Dengue Vector Bites
(American Society of Tropical Medicine and Hygiene, 2012) Souleymane Doucouré; François Mouchet; Amandine Cournil; Gilbert Le Goff; Sylvie Cornélie; Yelin Roca; Mabel Guerra Giraldez; Z. Barja Simon; Roxana Loayza; Dorothée Missé
Aedes mosquitoes are important vectors of re-emerging diseases in developing countries, and increasing exposure to Aedes in the developed world is currently a source of concern. Given the limitations of current entomologic methods, there is a need for a new effective way for evaluating Aedes exposure. Our objective was to evaluate specific antibody responses to Aedes aegypti saliva as a biomarker for vector exposure in a dengue-endemic urban area. IgG responses to saliva were strong in young children and steadily waned with age. Specific IgG levels were significantly higher in persons living in sites with higher Ae. aegypti density, as measured by using entomologic parameters. Logistic regression showed a significant correlation between IgG to saliva and exposure level, independently of either age or sex. These results suggest that antibody responses to saliva could be used to monitor human exposure to Aedes bites.
IL-17A, a possible biomarker for the evaluation of treatment response in Trypanosoma cruzi infected children: A 12-months follow-up study in Bolivia
(Public Library of Science, 2019) Clara Vásquez Velásquez; Graciela Russomando; Emilio E. Espínola; Zunilda Sánchez; Kota Mochizuki; Yelin Roca; Jimmy Revollo; Angelica Guzman; Benjamín Quiroga; Susana Rios Morgan
Plasma levels of IL-17A might be a bio-marker for detecting persistent infection of T. cruzi and its chronic inflammation.
La dynamique de la dengue à Santa Cruz de la Sierra (Bolivie) entre paysages à risques et mobilités
(Lille University of Science and Technology, 2011) Marianne Donnat; Bertha Gozalvez-Kreuzer; Yelin Roca; Adhémar Conde Cosme; Jacobo Choque Rios; Jean-Pierre Hervé; Pascal Handschumacher
La dengue, maladie transmise par un vecteur du genre aedes, est largement inféodée aux milieux urbains en raison des exigences écologiques de son vecteur qui se reproduit dans les multiples collections d’eau générées par la ville et ses habitants. Cependant la diversité des paysages urbains semble entraîner des hétérogénéités importantes de distribution de la maladie au sein même de la ville. Si la diffusion de la maladie à l’échelle du globe s’appuie sur le développement du fait urbain et notamment ses formes mal contrôlées, ainsi que sur l’accélération des déplacements de populations, peut-on expliquer l’hétérogénéité de la transmission en ville par les mêmes phénomènes mais dans leurs manifestations à grande échelle ? L’étude du cas de Santa Cruz de la Sierra, ville en pleine croissance d’un million et demi d’habitants, carrefour de circulation et « épicentre » de la maladie en Bolivie doit nous permettre de discuter de l’interaction entre les différents niveaux de déterminants pour une meilleure prise en compte du risque sanitaire dans les politiques de développement urbain. Une analyse critique de l’information et des résultats nous permet de mieux comprendre quelles inégalités sont révélées par la dengue pour une meilleure prise en charge de celles-ci.
Lineage Analysis of Circulating Trypanosoma cruzi Parasites and Their Association with Clinical Forms of Chagas Disease in Bolivia
(Public Library of Science, 2010) Florencia del Puerto; Juan Eiki Nishizawa; Mihoko Kikuchi; Naomi Iihoshi; Yelin Roca; Cinthia Avilas; Alberto Gianella; Javier Lora; Freddy Udalrico Gutierrez Velarde; Luis Alberto Renjel
None of the identified lineages or sublineages was significantly associated with any particular clinical manifestations in the chronic Chagas patients in Bolivia.
Molecular Epidemiological Analysis of Dengue Fever in Bolivia from 1998 to 2008
(Mary Ann Liebert, Inc., 2009) Yelin Roca; Cécile Baronti; Roberto Jimmy Revollo; Shelley Cook; Roxana Loayza; Läétitia Ninove; Roberto Fernández; Jorge Vargas Flores; Jean-Pierre Hervé; Xavier de Lamballerie
Dengue fever was first recognized in Bolivia in 1931. However, very limited information was available to date regarding the genetic characterization and epidemiology of Bolivian dengue virus strains. Here, we performed genetic characterization of the full-length envelope gene of 64 Bolivian isolates from 1998 to 2008 and investigated their origin and evolution to determine whether strains circulated simultaneously or alternatively, and whether or not multiple introductions of distinct viral variants had occurred during the period studied. We determined that, during the last decade, closely related viruses circulated during several consecutive years (5, 6, and 6 years for DENV-1, DENV-2, and DENV-3, respectively) and the co-circulation of two or even three serotypes was observed. Emergence of new variants (distinct from those identified during the previous episodes) was identified in the case of DENV-1 (2007 outbreak) and DENV-2 (2001 outbreak). In all cases, it is likely that the viruses originated from neighboring countries.
Molecular Epidemiology of Yellow Fever in Bolivia from 1999 to 2008
(Mary Ann Liebert, Inc., 2010) Cécile Baronti; Norma Janeth Velasquez Goitia; Shelley Cook; Yelin Roca; Jimmy Revollo; Jorge Vargas Flores; Xavier de Lamballerie
Yellow fever (YF) is a serious public health problem in Bolivia since at least the 19th century. Surprisingly, very limited information has been made available to date regarding the genetic characterisation and epidemiology of Bolivian YF virus (YFV) strains. Here, we conducted the genetic characterization of 12 human isolates of YFV collected in Bolivia between 1999 and 2008, by sequencing and analysis of two regions of the viral genome: a fragment encoding structural proteins "PrM" (premembrane and envelope) and a distal region "EMF," spanning the end of the virus genome. Our study reveals a high genetic diversity of YFV strains circulating in Bolivia during the last decade: we identified not only "Peruvian-like" genotype II viruses (related to previously characterized Bolivian strains), but also, for the fist time, "Brazilian-like" genotype I viruses. During the complete period of the study, only cases of "jungle" YF were detected (i.e., circulation of YFV via a sylvatic cycle) with no cluster of urban cases. However, the very significant spread of the Aedes aegypti mosquito across Bolivian cities threatens the country with the reappearance of an urban YFV transmission cycle and thus is required a sustained epidemiological surveillance.
Natural vertical transmission of dengue viruses by<i>Aedes aegypti</i>in Bolivia
(EDP Sciences, 2011) Gilbert Le Goff; Jane Yen Revollo; Maria Madalena Pessoa Guerra; M. Cruz; Z. Barja Simon; Yelin Roca; Jorge Vargas Flores; Jean-Pierre Hervé
The natural transmission of dengue virus from an infected female mosquito to its progeny, namely the vertical transmission, was researched in wild caught Aedes aegypti during an important outbreak in the town of Santa Cruz de la Sierra, Bolivia. Mosquitoes were collected at the preimaginal stages (eggs, larvae and pupae) then reared up to adult stage for viral detection using molecular methods. Dengue virus serotypes 1 and 3 were found to be co-circulating with significant higher prevalence in male than in female mosquitoes. Of the 97 pools of Ae. aegypti (n = 635 male and 748 female specimens) screened, 14 pools, collected in February-May in 2007, were found positive for dengue virus infection: five DEN-1 and nine DEN-3. The average true infection rate (TIR) and minimum infection rate (MIR) were respectively 1.08% and 1.01%. These observations suggest that vertical transmission of dengue virus may be detected in vectors at the peak of an outbreak as well as several months before an epidemic occurs in human population.
Protective Human Leucocyte Antigen Haplotype, HLA-DRB1*01-B*14, against Chronic Chagas Disease in Bolivia
(Public Library of Science, 2012) Florencia del Puerto; Juan Eiki Nishizawa; Mihoko Kikuchi; Yelin Roca; Cinthia Avilas; Alberto Gianella; Javier Lora; Freddy Udalrico Gutierrez Velarde; Sachio Miura; Norihiro Komiya
This is the first report of HLA haplotype association with resistance to chronic Chagas disease.