Molecular Attenuation Process in Live Vaccine Generation for Arenaviruses

Abstract

Lymphocytic Choriomeningitis (LCM, caused by LCMV), Lassa Fever (LF caused by LASV), Argentine Hemorrhagic Fever (AHF, caused by JUNV), Bolivian Hemorrhagic Fever (BHF, caused by MACV), Venezuelan Hemorrhagic Fever (VHF, caused by GTOV), and Brazilian Hemorrhagic Fever (BrHF, caused by SABV). The physiopathology of the hemorrhagic fevers produced by NWA is very similar. AHF and BHF were described in the middle of the twentieth century. GTOV was isolated from humans during an epidemic outbreak (at first mistaken for hemorrhagic dengue) that happened in Venezuela Because GTOV and PIRV share the same (geographic) area, different studies were made with the aim of predicting a re-emergence of a Venezuelan hemorrhagic fever variant The Brazilian hemorrhagic fever was established from a human fatal case, isolating the SABV Recently, a serological screening for arenavirus among the population of Nova Xavantina, State of Mato Grosso in Brazil, show that 1,4% of the serum samples presented antibody titers against arenavirus