Nationwide Implementation of Double Reflex Testing for Hepatitis Delta in Spain: Results From the Retrospective Phase of the Spain‐DDR Study

Ana AlberolaAdolfo de SalazarA. FuentesRaquel. Turrienzo CarracedoMarta Illescas‐LópezMaría del Carmen Rodríguez BañosCarolina FreyreBerta Cristina Soria BecerrilIsabel María Huertas VicianaInmaculada López‐Rodríguez2026-03-222026-03-22202610.1111/apt.70543https://doi.org/10.1111/apt.70543https://andeanlibrary.org/handle/123456789/79510Between 2022 and 2024, double reflex diagnostic implementation expanded rapidly, demonstrating national feasibility and describing hepatitis D virus seroprevalence. However, regional inequities persist. Sustained uptake will require standardised reflex protocols, harmonization of viral load assays and continuous training to reduce underdiagnosis and improve care of coinfected patients.enMedicineHepatitis C virusReflexHarmonizationIntensive care medicineHepacivirusHepatitis CMEDLINEHEPATITIS DELTARetrospective cohort studyNationwide Implementation of Double Reflex Testing for Hepatitis Delta in Spain: Results From the Retrospective Phase of the Spain‐DDR Studyarticle