Daniel LinaresBeatriz LunaEdson LoayzaAngela del CallejoMaria Garcia-SejasCarlos ErósteguiGonzalo Taboada2026-03-222026-03-22202510.1016/j.earlhumdev.2025.106270https://doi.org/10.1016/j.earlhumdev.2025.106270https://andeanlibrary.org/handle/123456789/52043Citaciones: 2Our findings indicate that both maternal and environmental factors, particularly high-altitude exposure, play a crucial role in the development of congenital anomalies in newborns with Down syndrome. These results underscore the need for enhanced surveillance and tailored clinical management in high-risk populations, as well as further research into preventive strategies to mitigate these risks.enMedicineEffects of high altitude on humansPediatricsDown syndromeAltitude (triangle)article