Glendy Polanco-HernándezFabiola Escalante‐ErosaKarlina García‐SosaMaría E. RosadoEugenia Guzmán-Marı́nKarla Y. Acosta-VianaAlberto Giménez-TurbaEfraín SalamancaLuis M. Peña-Rodrı́guez2026-03-222026-03-22201310.1155/2013/435398https://doi.org/10.1155/2013/435398https://andeanlibrary.org/handle/123456789/47386Citaciones: 21The in vitro trypanocidal activity of a 1 : 4 mixture of lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50 = 10.4 μ g/mL, FIC = 0.46). In addition, testing of the terpenoid mixture for its capacity to reduce the number of amastigote nests in cardiac tissue and skeletal muscle of infected mice showed a reduction of more than 80% at a dose level of 20.8 mg·kg(-1)·day(-1).enTerpenoidTrypanosoma cruziChemistryarticle