Rodriguez, PatriciaTruyens, CarineAlonso-Vega, CristinaFlores, AmilcarCordova, MarisolSuarez, EduardoTorrico, FaustinoCarlier, Yves2026-03-242026-03-2420050037-8682PMID:16482817https://pubmed.ncbi.nlm.nih.gov/16482817/https://andeanlibrary.org/handle/123456789/101386Vol. 38 Suppl 2, pp. 62-4This study compares the levels of specific antibodies IgM and IgA for Chagas in samples of blood from newborns. Three groups of cord blood samples have been analysed: a group of 42 samples from newborns, displaying positive parasitemia, of seropositive mothers (M+B+), 68 samples from newborns with negative parasitemia whose mothers were seropositive (M+B-) and a group of 45 control newborns coming from mothers with negative serology for Chagas. From the 42 M+B+ samples with congenital Chagas disease, 81 and 82.9% displayed detectable levels of IgM and IgA antibodies, respectively In the M+B- group, 70.6 and 33.8% presented antibodies of IgM and IgA classes, respectively, whereas in the control group M-B-, we detected 6% and 11.1% of IgM and IgA antibodies, respectively. The calculated sensitivity of detection of congenital cases using IgM or IgA antibodies was of 82.9% and 80.9% respectively, whereas the specificity of detection was of 29.4% for IgM antibodies and of 66.1% for IgA antibodies.spaArtículo Científico Publicado