John LondoñoAna María SantosPedro SantosMaria Fernanda CubidezC. Viqueira GuzmánRafael Valle‐Oñate2026-03-222026-03-22201210.1590/s0482-50042012000600003https://doi.org/10.1590/s0482-50042012000600003https://andeanlibrary.org/handle/123456789/47449Citaciones: 19The combination of MTX + LFN is effective for treating RA in patients for whom conventional treatment has failed. Strict medical and laboratory control is to be enforced for safety.ptMedicineGynecologyEficácia terapêutica e segurança de metotrexato + leflunomida em pacientes colombianos com artrite reumatoide ativa refratária ao tratamento convencionalarticle