Valdivia, Ana CBoketof, ÅkeOlde, BjörnOwman, ChristerVilaseca, AntonioFuentes, LennySterner, Olov2026-03-232026-03-232009http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S0250-54602009000200005&tlng=eshttps://andeanlibrary.org/handle/123456789/87811Vol. 26, No. 2The bio-guided fractionation of an ethanol extract of Baccharis genistelloides (L) Baker, a plant that traditionally is used to treat diabetes, yielded (+)-curcuphenol (1) as agonist of GPR40, a cell surface receptor for free fatty acids. This paper describes the agonistic activity of 1 as well as of a series of semi-synthetic and synthetic analoguesThe bio-guided fractionation of an ethanol extract of Baccharis genistelloides (L) Baker, a plant that traditionally is used to treat diabetes, yielded (+)-curcuphenol (1) as agonist of GPR40, a cell surface receptor for free fatty acids. This paper describes the agonistic activity of 1 as well as of a series of semi-synthetic and synthetic analoguesesGPR40Baccharis genistelloides(+)-Curcuphenol(+)-Curcuphenol-methyl-ether(+)-Dihydrocurcuphenol1-Bisabolone1-BisabololGlobulolBacchopetioloneArtículo Científico Publicado