Sandra BarralZikun YangNicole PhillipsRobert C. BarberAdam M. BrickmanLawrence S. HonigBasilio CiezaDolly Reyes‐DumeyerRichard MayeuxFarid Rajabli2026-03-222026-03-22202510.1002/alz.70138https://doi.org/10.1002/alz.70138https://andeanlibrary.org/handle/123456789/46519Citaciones: 3The apolipoprotein E (APOE) ε4 effect is stronger in Peruvians/Bolivians than in other Hispanic/Latino groups. The strong APOE effect size in Peruvians and Bolivians was replicated in a second independent Peruvian cohort. Meta-analysis for ε4 and ε2 confirmed a significant association with Alzheimer's disease and related dementias (ADRD). Global and local ancestry do not modify the association between APOE genotype and ADRD.enDiseaseGerontologyApolipoprotein EDementiaAlzheimer's diseaseMedicinePsychologyPsychiatryarticle