Author response: Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC)

Constanza Salinas-RebolledoJavier BlesaGuillermo Valenzuela-NietoDavid SchwefelNatalia López-González del ReyMaxs Méndez-RuetteJanine BurkhalterElizabeth CarrazanaFrancisca Díaz-TejedaIgnacio Arias Catalán2026-03-222026-03-22202510.7554/elife.101496.sa2https://doi.org/10.7554/elife.101496.sa2https://andeanlibrary.org/handle/123456789/87034Synthetic adaptors combining camelid nanobodies with the UBX domain of the p97 adaptor FAF1 enable targeted substrate delivery to p97, establishing an E3 ubiquitin ligase-independent mechanism for selective protein degradation.Chimera (genetics)ProteolysisUbiquitinChemistryCell biologySignal transducing adaptor proteinUltrabithoraxAAA proteinsFusion proteinDomain (mathematical analysis)Author response: Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC)peer-review