Silvia Diz‐de AlmeidaRaquel CruzAndré Ducati LuchessiJosé M. Lorenzo-SalazarMiguel López de HerediaInés QuintelaRafaela González‐MontelongoVivian Nogueira SilbigerMarta Sevilla PorrasJair Tenorio2026-03-222026-03-22202410.7554/elife.93666.1https://doi.org/10.7554/elife.93666.1https://andeanlibrary.org/handle/123456789/83520Citaciones: 1Abstract The genetic basis of severe COVID-19 has been thoroughly studied and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we have conducted the largest GWAS meta-analysis for COVID-19 hospitalization in admixed Americans, comprising a total of 4,702 hospitalized cases recruited by SCOURGE and other seven participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and first discovered in Latin-American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort.enCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakGeographyMedicineDemographyVirologypreprint