Rosa M. Sánchez-HernándezFernando CiveiraMarianne StefSofía Pérez‐CalahorraFátima AlmagroNúria PlanaFrancisco J. NóvoaPedro Sáenz-AranzubíaDaniel MosqueraCristina Soler2026-03-222026-03-22201610.1161/circgenetics.116.001545https://doi.org/10.1161/circgenetics.116.001545https://andeanlibrary.org/handle/123456789/43537Citaciones: 71HoFH frequency in Spain was higher than expected. Clinical criteria would underestimate the actual prevalence of individuals with genetic HoFH, highlighting the importance of genetic analysis to improve familial hypercholesterolemia diagnosis accuracy.enFamilial hypercholesterolemiaPCSK9LDL receptorApolipoprotein BMedicineCompound heterozygosityDyslipidemiaInternal medicineDiseaseLipoproteinarticle