Lindsay McKennaMike FrickValentina Alarcon-GuizadoGeraint DaviesJennifer FurinL. GuglielmettiNorbert HeinrichMarcus LowMariama MahmoudV. Mave2026-03-222026-03-22202610.1093/cid/ciag175https://doi.org/10.1093/cid/ciag175https://andeanlibrary.org/handle/123456789/80046Tuberculosis treatment trials have used various comparison strategies. To inform trial design for novel tuberculosis regimens, we applied an existing framework for evaluating when uncontrolled trials might be justified. We conclude that the conditions are not met for tuberculosis treatment and that uncontrolled phase 3 trials should not be performed.enMedicineClinical trialTuberculosisIntensive care medicineTb treatmentTuberculosis vaccinesMEDLINEResearch designAlternative medicineClinical study designarticle