Federica MaccarinelliMaria RegoniFernando CarmonaMaura PoliEsther G. Meyron‐HoltzPaolo Arosio2026-03-222026-03-22201710.1071/rd16348https://doi.org/10.1071/rd16348https://andeanlibrary.org/handle/123456789/45630Citaciones: 18Mitochondrial ferritin (FtMt) is a functional ferritin targeted to mitochondria that is highly expressed in the testis. To investigate the role of FtMt in the testis we set up a series of controlled matings between FtMt gene-deletion mice (FtMt^-/-) with FtMt^+/+ mice. We found that the number of newborns per litter and the fertility rate were strongly reduced for the FtMt^-/- males, but not for the females, indicating that FtMt has an important role for male fertility. The morphology of the testis and of the spermatozoa of FtMt^-/- mice was normal and we did not detect alterations in sperm parameters or in oxidative stress indices. In contrast, we observed that the cauda epididymides of FtMt^-/- mice were significantly lighter and contained a lower number of spermatozoa compared with the controls. Also, the ATP content of FtMt^-/- spermatozoa was found to be lower than that of FtMt^+/+ spermatozoa. These data show that FtMt contributes to sperm epididymis maturation and to male fertility.enBiologyEpididymisSpermFertilityAndrologySemenMolecular biologyarticle