Sandra G. ZárateÁgatha BastidaAndrés G. SantanaJulia Revuelta2026-03-222026-03-22201910.3390/antibiotics8030109https://doi.org/10.3390/antibiotics8030109https://andeanlibrary.org/handle/123456789/51427Citaciones: 3A novel protocol has been established to prepare the kanamycin ring II/III fragment, which has been validated as a minimum structural motif for the development of new aminoglycosides on the basis of its bactericidal activity even against resistant strains. Furthermore, its ability to act as a AAC-(6') and APH-(3') binder, and as a poor substrate for the ravenous ANT-(4'), makes it an excellent candidate for the design of inhibitors of these aminoglycoside modifying enzymes.enKanamycinAminoglycosideChemistryAntibioticsFragment (logic)StereochemistryMotif (music)Ring (chemistry)Combinatorial chemistryarticle