Pedro-Ivan Navarro-NaranjoAlberto Chacon-ApontoGerardo Artunduaga-RodriguezDaniela Duran-Moreno2026-03-222026-03-22202310.21203/rs.3.rs-3222041/v1https://doi.org/10.21203/rs.3.rs-3222041/v1https://andeanlibrary.org/handle/123456789/83851Citaciones: 1Abstract Objective: To describe the clinical effects of a novel combined ocular lubricant for treating patients with dry eye disease. Methods : A retrospective cohort of 67 eyes (67 patients) with a confirmed diagnosis of dry eye disease using the ocular surface disease index (>12), tear osmolarity and ocular surface parameters (non-invasive break-up time, meniscus height and meibography) evaluated using the Cornea550 were included. All patients were treated with a combination of 0.5% carboxymethylcellulose, glycerin 0.9% and trehalose 3% with a dosing regimen of one drop four times a day for one month with a final evaluation of the same parameters. Results : We included 67 eyes (80.6% females) with a mean age of 48.3+/-16.2 years (SD). 37% of the subjects had comorbidities such as hypothyroidism (9%), ocular rosacea (4%), Sjogren’s syndrome (4%) and arterial hypertension (4%). Of these, 34% were taking systemic medications and 56.7% had previous ocular surgery. The mean OSDI score before treatment was 57.6 +/- 17.2 (SD) and 22.2 +/-12.9 points (SD) after treatment ( p <0.05). Other parameters such as NIBUT, meniscus height and meibography improved without a statistically significant difference. Conclusion: CTP is a novel, combined and multipurpose treatment for dry eye disease.enMedicineOphthalmologyCohortSurgeryInternal medicinepreprint