The reaction of aromatic α,β‐unsaturated ketones with 4,5‐diamino‐1,6‐dihydropyrimidin‐6‐ones

Braulio InsuastyMÓNica RamosJairo QuirogaAdolfo SánchezManuel NoguerasNorbert HanoldHerbert Meier2026-03-222026-03-22199410.1002/jhet.5570310111https://doi.org/10.1002/jhet.5570310111https://andeanlibrary.org/handle/123456789/53779Citaciones: 30Abstract The reaction of 4,5‐diamino‐1,6‐dihydropyrimidin‐6‐ones 1 with one equivalent of the chalcones 2 leads in an acidic medium to the formation of the 2,4‐diaryl‐2,3,6,7‐tetrahydro‐1 H ‐pyrimido[4,5‐ b ][1,4]diazepin‐6‐ones 3a‐m . The structure elucidation of the products is based on detailed nmr investigations including selective 13 C[ 1 H] decoupling experiments.enChemistryDecoupling (probability)Medicinal chemistryOrganic chemistryStereochemistryComputational chemistryThe reaction of aromatic α,β‐unsaturated ketones with 4,5‐diamino‐1,6‐dihydropyrimidin‐6‐onesarticle