Christian MorettiMichel SauvainCatherine LavaudGeorges MassiotJosé A. BravoVerónica Francisca Loewe Muñoz2026-03-222026-03-22199810.1021/np9800654https://doi.org/10.1021/np9800654https://andeanlibrary.org/handle/123456789/46879Citaciones: 69A new aminosteroid, 3beta-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-beta-D-glucopyranosyl-eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 microM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 microM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.enEriodictyolAntiprotozoalLeishmania braziliensisTrypanosoma cruziAlkaloidIn vitroPharmacognosyStereochemistryBiologyLeishmaniaarticle