Simonazzi, AnalíaCid, Alicia GracielaParedes, Alejandro JavierSchofs, LaureanoGonzo, Elio EmilioPalma, Santiago DanielBermúdez, José María2026-03-242026-03-2420182041-6008PMID:3018980810.4155/tde-2018-0037https://doi.org/10.4155/tde-2018-0037https://andeanlibrary.org/handle/123456789/101115Vol. 9, No. 9, pp. 623-638AIM: Solid dispersions using Poloxamer 407 as carrier were developed to improve albendazole (ABZ) solubility and dissolution profiles. METHODS: ABZ/poloxamer solid dispersions were prepared, and dissolution profiles were mathematically modeled and compared with physical mixtures, pharmaceutical ABZ and a commercial formulation. RESULTS: Poloxamer 407 increased exponentially ABZ solubility, in about 400% when 95% w/w of polymer compared with its absence. Solid dispersions initial dissolution rate was three to 20-fold higher than physical mixtures, the drug and the commercial formulation. All the solid dispersions required less than 2.2 min to reach an 80% of ABZ dissolution, while the commercial formulation needed around 40 min. CONCLUSION: Solid dispersions improved ABZ solubility and dissolution rate, which could result in a faster absorption and an increased bioavailability.engalbendazoledissolution efficiencyinitial dissolution ratelumped modelpoloxamersolid dispersionssolubilityArtículo Científico Publicado