Sully M. CruzArmando CáceresLuis E. ÁlvarezJorge Alexander Diaz MoralesMiriam Anders ApelAmélia Teresinha HenriquesEfraín SalamancaAlberto GiménezYelkaira VásquezMahabir P. Gupta2026-03-222026-03-22201110.1590/s0102-695x2011005000110https://doi.org/10.1590/s0102-695x2011005000110https://andeanlibrary.org/handle/123456789/47469Citaciones: 18The essential oils from two native species from Guatemala were studied for their chemical composition and the dichloromethane and methanol extracts for their biological activity. A GC-MS analysis of the essential oil from Piper jacquemontianum Kunth, Piperaceae, showed 34 constituents, consisting mainly of linalool (69.4%), while Piper variabile C. DC. essential oil had 36 constituents, camphor (28.4%), camphene (16.6%) and limonene (13.9%) being the major components. Dichloromethane extracts of both species were cytotoxic against MCF-7, H-460 and SF-268 cell lines (<7 µg/mL). Dichloromethane extract of P. jacquemontianum was slightly active against bacteria (0.5 mg/mL), was active against promastigotes of Leishmania (20.4-61.0 µg/mL), and epimastigotes of Trypanosoma cruzi (51.9 µg/mL). The methanol extract of P. variabile showed antimalarial activity against Plasmodium falciparum F32 (4.5 µg/mL), and the dichloromethane extract against Leishmania (55.8-76.3 µg/mL) and T. cruzi (45.8 µg/mL). None of the extracts from the two species was active against Aedes aegypti larvae and Artemia salina nauplii.enPiperaceaePiperCamphorDichloromethaneEssential oilCampheneLinaloolArtemia salinaTraditional medicineBiologyarticle